Skip to main content
OpenTrials
Completed

NCT Number: NCT00387257

Effect Of Rilapladib (SB-659032) On Platelet Aggregation

The purpose of this study is to compare the effects of repeat doses of SB-659032 with placebo on platelet aggregation in subjects.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy Subjects Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Cardiovascular Diseases Vascular Diseases

Age range

18 year–55 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 1

Primary location

GSK Investigational Site

Randwick, New South Wales, 2031, Australia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects with QTc < 450 msec as measured at screening.

Exclusion criteria

  • History of asthma.
  • Smokers.

Treatment and study plan

Rilapladib (SB-659032)

Drug

Primary outcomes

  1. Collagen EC50 values on Day 35 (or 21 days post last dose) as determine by optical aggregometry.

    Time frame: on Day 35 (or 21 days post last dose) as determine by optical aggregometry

Secondary outcomes

  1. Collagen EC50 values on Day 1 and Day 14 as determined by optical aggregometry Plasma Lp-PLA2 activity Clinical safety data Concentrations of rilapladib and SB-664601.

    Time frame: on Day 1 and Day 14 as determined by optical aggregometry

Sponsors and collaborators

Lead sponsor

GlaxoSmithKline

Industry

Registry information

Official study title

A Double Blind, Placebo Controlled, Parallel Study to Evaluate Effects of Repeat Doses of Rilapladib on Platelet Aggregation in Healthy Male Volunteers

Important dates

Study start
2006
Primary completion
2007
Study completion
2007
First posted
Oct 12, 2006
Registry last updated
Apr 15, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.