Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07395531

Effect of Repetitive Bihemispheric Anodal Transcranial Direct Current Stimulation on Motor Function of Patients With Parkinson's Disease

Dopaminergic medications and Deep Brain Stimulation (DBS) are the current standards interventions for Parkinson's Disease. Pharmacotherapy with dopaminergic drugs leads to partial improvement in motor functions of patients. Invasive therapies like DBS have as yet limited availability and accessibility, with risk of adverse events as well. Non invasive therapies like Transcranial Direct Current Stimulation (tDCS) are currently increasingly being probed for their therapeutic value, in view of their safety, portability and convenience of administration.

Improvement in motor function immediately after a single session of tDCS has been observed. The effect of single simulation is not sustained beyond a few days. Only few studies with varied sites of stimulation have evaluated the effect of repetitive tDCS on motor function improvement in patients with Parkinson's Disease, with conflicting results. There is an unmet need to probe the utility of repetitive tDCS on motor function of patients with Parkinson's Disease.

We aim to probe the effect of repetitive tDCS of dorsolateral prefrontal cortex and M1 cortex on motor function in patients with Parkinson's Disease (Hoehn and Yahr stage 2 to 4).

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

PARKINSON DISEASE (Disorder) Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients fulfilling the Movement Disorder Society (MDS) clinical diagnostic criteria for Parkinson's disease.
  • Patients with Hoehn & Yahr stages 2-4 Parkinson's disease.
  • Patients maintained on stable medical regimen for at least 1 month before entering the study.

Exclusion criteria

  • Patients with other confounding neurological and psychiatric disorders.
  • The presence of metal objects or stimulators in the head.
  • Patients with a history of deep brain stimulation.
  • Patients with history of seizures.
  • Patients with skull defect due to surgery e.g. craniectomy
  • Patients with scalp condition likely to obstruct application of electrodes.

Treatment and study plan

Transcranial Direct Current Stimulation

Device

Anodal tDCS stimulation

Other names: tDCS

Primary outcomes

  1. To determine change in motor function score as assessed by Movement Disorder Society - Unified Parkinson's Disease Rating Scale Part - III scale 1 week after the repetitive tDCS (Minimum Score 0, Maximum Score 132, higher scores indicate more disability)

    Time frame: 1 week

Secondary outcomes

  1. To determine the change in Timed Up and Go test score of patients with Parkinson's Disease at 1 week after the repetitive tDCS (higher times indicate disability with increased risk of fall)

    Time frame: 1 week

Study contacts

Contact information is provided by the study sponsor or research team.

Ashish Kumar Duggal, Doctor (Professor)

CONTACT

[email protected]

+919810523332

Devavrata Sahu, Doctor

CONTACT

[email protected]

+918800815928

Sponsors and collaborators

Lead sponsor

Dr. Ram Manohar Lohia Hospital

Other Gov

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 9, 2026
Registry last updated
Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.