Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection

Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. It is known that one-lung ventilation in patients undergoing pulmonary resection, which may cause acute lung injury. The investigators did a single-blinded randomised controlled study to establish whether remote ischemic preconditioning reduces lung injury in these patients.

Inclusion criteria

• Clinical diagnosis of pulmonary carcinoma
• Must be received pulmonary lobectomy

Exclusion criteria

• Cardiac disease categorized as NYHA classes II-IV
• Preoperative severe impairment of respiratory function (arterial oxygen tension (PaO2) <60 mmHg or FEV1<50% predicted),
• Pre-existing coagulopathy or thrombocytopenia
• Prior receipt of chemotherapy or radiation therapy or immunotherapy
• Systemic or local active infections (either clinically defined or suggested by evidence such as elevated C-reactive protein levels, leukocytosis, or a body temperature>38℃)
• Peripheral vascular disease affecting the upper limbs
• Administration of vitamins, nonsteroidal anti-inflammatory agent or corticosteroid within 3 months.