Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery

This study is conducted in order to evaluate the effect of remote ischemic preconditioning on children undergoing cardiac surgery, especially focusing on possible differences according to preoperative cyanosis.

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Key information

Conditions

Cyanosis Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

1 month–10 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital, Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

open heart surgery under cardiopulmonary bypass: ventricular septal defect, tetralogy of Fallot

Exclusion criteria

chromosomal defect
airway and parenchymal lung disease blood disorder
isolated atrail septal defect
immunodeficiency

Treatment and study plan

RIPC (remote ischemic preconditioning)

Other

RIPC will be performed by four 5-min cycles of lower limb ischemia and 5 in reperfusion using blood-pressure cuff inflated to a pressure 15 mmHg greater than the systolic arterial pressure measured via arterial line.

Primary outcomes

troponin level

Time frame: within the 1 day after operation

troponin level will be checked 1, 6, 12 and 24 hours after operation. Ater making a graph (troponin-time), area under the curve will bw calculated.

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery: Implication of Preoperative Cyanosis

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2011
First posted: Mar 9, 2011
Registry last updated: May 1, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed