Effect of Remote Ischemia Preconditioning on Myocardial Injury in Patients Undergoing Heart Valve Surgery

Remote ischaemic preconditioning has shown its cardiac protective effect during heart surgery including coronary artery bypass graft surgery, congenital heart disease and aneurysm. However, no data was reported on heart valve disease surgery. Rheumatic heart disease is one of the major heart diseases requiring surgery in China. Thus, the investigators chose heart valve disease as a focus to see whether remote ischaemic preconditioning also has cardiac protective effect during heart valve surgery.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Heart Valve Diseases Bacterial Infections Bacterial Infections and Mycoses Cardiovascular Diseases Gram-Positive Bacterial Infections Heart Diseases Heart Valve Prolapse Infections Rheumatic Fever Rheumatic Heart Disease Streptococcal Infections

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Guangzhou First Municipal People's Hospital

Guangzhou, Guangdong, 510180, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All heart valve diseases needing heart valve surgery.

Exclusion criteria

All four limbs existed ischemic condition

Treatment and study plan

Remote ischaemic preconditioning

Procedure

Remote ischaemic preconditioning consisted of three 5-min cycles of right upper arm ischaemia, which was induced by an automated cuff -inflator placed on the right upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated. There was a 5- to 10-min interval between completion of the remote ischaemic preconditioning protocol and initiation of bypass.Control patients had a deflated cuff placed on the right upper arm for 30 min.

Primary outcomes

plasma troponin I level

Time frame: with 7 days after surgery

The investigators will measure the plasma troponin I level in several time points before and after surgery in each patient.

Secondary outcomes

serum creatinine

Time frame: within 7 days after surgery

Sponsors and collaborators

Lead sponsor

Sun Yat-sen University

Other

Collaborators

Guangzhou First People's Hospital

Registry information

Important dates

Study start: 2007
Primary completion: 2011
Study completion: 2011
First posted: Aug 5, 2010
Registry last updated: Jul 21, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Not Yet Recruiting