Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07063563

Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in COPD-patients

Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

COPD Behavior Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National center for cardiology and internal medicine, Bishkek, Kyrgyzstan

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged ≥18 years
  • Stable clinical condition for >3 weeks (e.g., no exacerbations)
  • Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT
  • Informed consent documented by signature

Exclusion criteria

  • Severe daytime resting hypoxemia (SpO₂ <88%)
  • Long-term oxygen therapy
  • Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities
  • Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)
  • Women who are pregnant or breastfeeding
  • Enrolment in another clinical trial involving active treatment

Treatment and study plan

ambiant air

Other

Standard ambiant air will be breathed during endurance training. ambiant air

Oxygen

Other

SSOT and sham air (5l/min) will be applied with the oxygen concentrator EverFloTM via nasal cannula during training

Primary outcomes

  1. 1. Change in Rrs (Respiratory System Resistance) before and after rehabilitation cycle

    Time frame: baseline to 3 weeks

    Rrs will be measured using the forced oscillation technique (FOT) in cmH₂O·s/L. Values will be assessed before and after the pulmonary rehabilitation cycle at moderate altitude

Secondary outcomes

  1. Change in Xrs (Respiratory System Reactance) compared before and after the pulmonary rehabilitation.

    Time frame: baseline to 3 weeks

    Xrs will be measured using FOT in cmH₂O·s/L. Values will be compared before and after the pulmonary rehabilitation

  2. Change in ∆Xrs (Difference in Reactance) before and after rehabilitation

    Time frame: baseline to 3 weeks

    ∆Xrs will be calculated as the difference between inspiratory and expiratory Xrs values, measured in cmH₂O·s/L, before and after rehabilitation.

  3. Change in Rrs, Xrs and ∆Xrs from low to moderate altitude

    Time frame: From baseline at low altitude to transfer to moderate altitude at 3 days

Study contacts

Contact information is provided by the study sponsor or research team.

Stéphanie Saxer, Dr.

CONTACT

[email protected]

+41 58 257 12 97

Sponsors and collaborators

Lead sponsor

Eastern Switzerland University of Applied Sciences

Other

Collaborators

  • National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
  • University of Zurich

Registry information

Official study title

Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in Patients With COPD

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 14, 2025
Registry last updated
Jul 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.