Effect of Regional Versus General Anesthesia on Thirty-day Outcomes Following Carotid Endarterectomy: a Matched-pairs Cohort Study.

The goal of this observational study is to assess the effect of regional versus general anesthesia on carotid endarterectomy thirty-day outcomes. The main questions it aims to answer are:

* Is regional anesthesia associated with lower incidence of major morbidity and mortality? * Is regional anesthesia associated with lower incidences of secondary adverse events?

Participants will be sampled from the 2015-2019 American College of Surgeons National Surgical Quality Improvement Program

Completed

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Key information

Conditions

Regional Anesthesia Morbidity Brain Diseases Cardiovascular Diseases Carotid Artery Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Perioperative/Postoperative Complications Postoperative Complications Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Elective, non-emergent cases
Regional anesthesia
General anesthesia

Exclusion criteria

Concurrency in procedures
Acute kidney injury (preoperative)
End-stage renal disease (preoperative)
Metastatic disease (preoperative)
Wound infection (preoperative)
Sepsis (preoperative)
ASA 5

Treatment and study plan

Anesthetic technique (regional versus general)

Procedure

Anesthetic technique (regional versus general)

Primary outcomes

Major morbidity and mortality

Time frame: Thirty days

Stoke, myocardial infarction, or death

Secondary outcomes

Minor morbidity

Time frame: Thirty days

Reintubation, prolonged (>48 hour) ventilator dependence, pneumonia, deep venous thrombosis, pulmonary embolism, superficial surgical site infection (SSI), deep incisional SSI, organ space SSI, wound dehiscence, sepsis, septic shock, acute kidney injury, and progressive renal insufficiency
Bleeding events

Time frame: Thirty days

Requiring transfusion
Unplanned resource utilization

Time frame: Thirty days

Unplanned readmission and unplanned reoperation
Mortality

Time frame: Thirty days

Mortality

Sponsors and collaborators

Lead sponsor

University of Virginia

Other

Registry information

Important dates

Study start: 2015
Primary completion: 2019
Study completion: 2019
First posted: Jan 31, 2023
Registry last updated: Jan 31, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed