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Completed

NCT Number: NCT00876811

Effect of Red Raspberry Consumption on Fasting Oxidative Stress Biomarkers

The purpose of this study is determine whether daily consumption of frozen red raspberries can improve the antioxidant capacity of the blood and reduce the effects of oxidative stress, dose-dependently, in a healthy adult population.

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Key information

Conditions

Oxidative Stress

Age range

18 year–43 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

Toronto, Ontario, M5C 2T2, Canada

About this study

Red raspberries are an excellent source of numerous polyphenolic antioxidants. The bioactivity of these compounds have been implicated in many biological pathways and may function to reduce the risk of numerous chronic diseases. We are conducting an intervention study with frozen red raspberries on a healthy adult population in order to determine if raspberry polyphenols are bioavailable and bioactive in vivo. Twenty-four subjects (12 male and 12 female) will be recruited to participate and consume one-cup frozen red raspberries daily for two weeks, they then will randomly be assigned to consume either one, two or four cups of raspberries for another two weeks, this will be followed by four weeks of non-treatment. Blood samples and 12-hour urine collections will be taken in order to measure the concentration of raspberry polyphenols in response to treatment dose. Dose-dependent treatment effects on blood biomarkers for antioxidant capacity, oxidative stress, inflammation and other chronic disease risk factors will also be measured.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy adults

Exclusion criteria

  • obese (>30kg/m2)
  • high blood pressure (140/90mmHg)
  • allergic to raspberries
  • pregnant or lactating
  • history of chronic disease
  • currently taking medication

Treatment and study plan

individually quick frozen red raspberries

Dietary Supplement

Consumption of one-cup frozen red raspberries daily for four weeks, followed by a four week period of non-treatment.

Primary outcomes

  1. serum TBARS

    Time frame: end of week 1, 3, 5 and 9

    an indicator of MDA levels, and therefore, lipid peroxidation

Secondary outcomes

  1. serum antioxidant capacity (AOC)

    Time frame: end of week 1, 3, 5 and 9

    measured using the TEAC-ABTS radical cation assay

  2. serum thiols

    Time frame: end of week 1, 3, 5 and 9

    measured using the DTNB assay, as an indicator of antioxidant levels in protein fraction

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Collaborators

  • Unity Health Toronto

Registry information

Official study title

Raspberries and Human Health: A Short-term Intervention Trial Investigating the Effect of Daily Red Raspberry Consumption on Fasting Oxidative Stress Biomarkers

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
Apr 7, 2009
Registry last updated
Oct 29, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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