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NCT Number: NCT03725527

Effect of Rectus Sheath Block on Diaphragmatic Function After Elective Upper Abdominal Surgery

This study will be undertaken to investigate the respiratory and analgesic effects of ultrasound guided rectus sheath block analgesia after elective abdominal surgery with midline incision.

Recruiting

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

A major proportion of pain experienced by patients undergoing abdominal surgeries is due to somatic pain signals derived from the abdominal wall. The central portion of anterior abdominal wall components (skin, muscles and parietal peritoneum) is innervated by sensory neurons branching from the anterior rami of spinal nerves T7 to T1. These neurons lie between the rectus abdominis muscle and posterior rectus sheath, and pierce the rectus muscle close to the midline. The tendinous intersections of the rectus muscle do not fuse with the posterior rectus sheath, thereby allowing the injectate to spread cephalo-caudally within this potential space. Rectus sheath (RS) block has been described for any midline abdominal incisions (epigastric and umbilical hernia repairs). As visceral pain becomes attenuated by the 2nd postoperative day, rectus sheath block can also be administered for midline laparotomy.

However, the effects of rectus sheath block analgesia on the respiratory function after abdominal surgery with midline incisions are still under investigation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 18-50 years.
  • Sex: both males and females.
  • BMI< 30kg/m2.
  • ASA physical status: 1, II and III.
  • Elective abdominal surgery with midline incisions.

Exclusion criteria

  • Patient refusal.
  • Infection at injection site
  • Coagulation disorders.
  • Allergy to study medications.
  • Pregnancy.
  • Respiratory tract infection within the last 2 weeks.
  • Urgent abdominal surgery

Treatment and study plan

Rectus sheath block

Procedure

Sonar guided RSB will be performed using a 16-G, 8-cm TuohyUpon reaching this potential space, after careful aspiration.

Other names: RSB

Primary outcomes

  1. Diaphragmatic inspiratory amplitude during quiet/deep breathing (DIA)/cm

    Time frame: 24 hours Postoperative

    The ultrasonic measurements of diaphragmatic motion will be attained at the posterior surface of the diaphragm. From the tracings on M-mode, the distance between echogenic lines (DIA) in centimeters and diaphragmatic inspiratory/expiratory velocity in centimeters/second during quiet, deep, and sniff breathing will be measured on the frozen images.

Secondary outcomes

  1. Verbal Rating Scale

    Time frame: 24 hours Postoperatively

    Verbal rating pain scale (VRS) (Ranging from 0 to 4), where 0=no pain, 1=mild pain, 2=moderate pain, 3=severe pain and lastly 4 =excruciating pain) will be recorded at rest and upon patient coughing; on admission to PACU (baseline), and 2, 4, 6, 12, and 24h postoperatively.

  2. Forced Vital Capacity/L

    Time frame: 24 hours Postoperatively

    Measurements of Forced vital capacity (FVC) will be measured by the use of hand-held spirometer (One-flow®, Clement Clarke, U.K). At each assessment, the largest values of FVC will be recorded.

Study contacts

Contact information is provided by the study sponsor or research team.

Beshoy B Bolis, MBBCH

CONTACT

[email protected]

+2 01273774057

Noha Y Mohamed, MD

CONTACT

[email protected]

+2 01001890194

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Respiratory Effects of Rectus Sheath Block in Patients Undergoing Major Upper Abdominal Surgery.

Acronym: Rectus

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Oct 31, 2018
Registry last updated
Sep 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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