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Completed

NCT Number: NCT04377789

Effect of Quercetin on Prophylaxis and Treatment of COVID-19

Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. The investigators hypothesize that quercetin, as a strong scavenger and anti-inflammatory agent, can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

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Key information

Conditions

COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kanuni Sultan Suleyman Training and Research Hospital

Istanbul, 34303, Turkey (Türkiye)

About this study

Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. Quercetin is reported to be effective on treatment and prophylaxis of other SARS like coronavirus infections, as a strong antioxidant and scavenger flavonoid without any adverse events. Upon this data, the investigators hypothesize that quercetin can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • moderate-high risk for COVID-19
  • obtained informed consent

Exclusion criteria

  • declined to participate
  • genetic/chromosomal abnormalities
  • any kind of sensitivity or allergy for quercetin
  • history of previous hypersensitivity with quercetin

Treatment and study plan

Quercetin Prophylaxis

Dietary Supplement

a daily dose of quercetin (500mg) will be taken by non-COVID-19 intervention group 1

Quercetin Treatment

Dietary Supplement

a daily dose of quercetin (1000mg) will be taken by proven COVID-19 cases intervention group 2

Primary outcomes

  1. Prevalence of COVID-19 calculated using a questionnaire

    Time frame: 3 months

    Prevalence of COVID-19 in prophylaxis and sham group will be calculated using a questionnaire including hospital records

  2. Standardized Mortality rate

    Time frame: 3 months

    Mortality rate will be compared between two groups

Secondary outcomes

  1. Morbidity rate

    Time frame: 3 months

    Morbidity rates besides recovery rates from COVID-19 will be documented

Sponsors and collaborators

Lead sponsor

Kanuni Sultan Suleyman Training and Research Hospital

Other

Collaborators

  • Orbiteratec (funding)

Registry information

Official study title

The Possible Effect of Quercetin on Prophylaxis and Treatment of COVID-19

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
May 6, 2020
Registry last updated
Feb 18, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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