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Completed

NCT Number: NCT01732393

Effect of Quercetin in Prevention and Treatment of Oral Mucositis

The study aims to evaluate the effect of Quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.

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Key information

Conditions

Chemotherapy Induced Oral Mucositis Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Hematologic Diseases Hematologic Neoplasms Hemic and Lymphatic Diseases Mouth Diseases Mucositis Neoplasms Neoplasms by Site Stomatognathic Diseases

Age range

15 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Oral Medicine Department of Mashhad dental School

Mashhad, Razavi Khorasan Province, 91735-498, Iran

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient under chemotherapy
  • for a hematologic malignancy
  • the hematologist permits the trial on the patient
  • agreement of patient for participating in the trial

Exclusion criteria

  • presence pf ANY oral lesion at the beginning of the trial
  • loss of follow up
  • use of digoxin and cyclosporine
  • patient death

Treatment and study plan

oral quercetin capsules

Drug

10 cases in case group and 10 cases in control group. Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks. Patients in the placebo group received two placebo capsules containing lactose .Patients were examined every other day for evaluation of initiation and severity of oral mucositis.

Placebo

Drug

Primary outcomes

  1. lower grade of mucositis

    Time frame: 3 weeks

    grade of mucositis due to WHO criteria

Secondary outcomes

  1. duration of mucositis

    Time frame: 3 weeks of study tiem span and after trial

    duration of mucositis due to Who criteria

Sponsors and collaborators

Lead sponsor

Mashhad University of Medical Sciences

Other

Registry information

Official study title

Effect of Quercetin in Prevention and Treatment of Chemotherapy Induced Oral Mucositis in Blood Dyscrasias

Important dates

Study start
2010
Primary completion
2011
Study completion
2012
First posted
Nov 22, 2012
Registry last updated
Dec 5, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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