Effect of PVE on Surgical Outcomes and Long-term Survival in Perihilar Cholangiocarcinoma

Portal vein embolization is often recommended to reduce the risk of postoperative liver failure and mortality. In this retrospective cohort study, researchers investigated the effect of portal vein embolization in patients with resectable perihilar cholangiocarcinoma bismuth type III and IV.

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Key information

Conditions

Biliary Tract Cancer Biliary Tract Diseases Biliary Tract Neoplasms Digestive System Diseases Digestive System Neoplasms Neoplasms Neoplasms by Site Portal Vein Embolization

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, 03080, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with Bismuth type III or IV stricture on radiological examination, including computed tomography (CT) or magnetic resonance cholangiography
patients with perihilar cholangiocarcinoma histologically confirmed by surgical resection or forceps biopsy/brush cytology under endoscopic retrograde cholangiopancreatography or through the percutaneous transhepatic biliary drainage tract.

Exclusion criteria

patients with unresectable perihilar cholangiocarcinoma
patients who refused treatment
patients with other concomitant malignancies.

Treatment and study plan

Potal vein embilization

Procedure

Portal vein of involved bile duct is embolized to increase the volume of remnant liver.

Other names: Surgical resection

Primary outcomes

Overall survival

Time frame: The time from diagnosis until the date of death or last date of follow-up or end of study up to 24 months

Overall survival of each group (A-C).

Secondary outcomes

Recurrence free survival

Time frame: The time from surgical resection until the date of recurrence or death or last date of follow-up or end of study up to 24 months

Recurrence free survival of patients who underwent surgical resection

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Effect of Portal Vein Embolization on Surgical Outcomes and Long-term Survival in Patients With Perihilar Cholangiocarcinoma

Important dates

Study start: 2020
Primary completion: 2021
Study completion: 2023
First posted: Jan 25, 2024
Registry last updated: Jan 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed