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Completed

NCT Number: NCT05476835

Effect of Pulmonary Rehabilitation Program on Post Hospitalization Severe COVID- 19 Patients

COVID-19 infection was discovered to be the major global cause of a serious respiratory illness toward the end of 2019. The majority of COVID-19 patients experience mild disease, while about 14% go on to have severe disease and 6% end up in critical condition. An evidence-based standard of therapy called pulmonary rehabilitation includes exercise training, education, and behavior modification to help people with lung illness feel better physically and mentally.

The aim of the study to evaluate the effect of pulmonary rehabilitation program on severe post covid19 patients (post hospitalization) regarding pulmonary function tests and dyspnea score.

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Key information

Conditions

Post COVID-19 Condition

Age range

50 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fayoum University Hospital

Al Fayyum, Egypt

About this study

SARS CoV-2 infection has caused substantial death, morbidity, and unprecedented strain on the world's healthcare systems . When the illness is minor, it typically takes two weeks from the onset of symptoms till recovery, and when it is severe or critical, it may take three to six weeks. It should be mentioned that approximately 75% to 80% of hospitalized patients will remain there for more than 21 days .

After the virus is defeated, COVID-19 can have serious aftereffects on the patient, with bilateral pneumonia. As a result, physiotherapy is essential in this pandemic and will play a major role in helping many patients' health. A 20-30% reduction in pulmonary capacity has already been reported in recent studies .

Although pulmonary rehabilitation has been suggested following severe COVID-19, there is a lack of data showing effectiveness on recovery of physical and psychosocial parameters in severe COVID-19 patients following hospitalization.

The aim of the study is to evaluate the effect of pulmonary rehabilitation program on severe post covid19 patients (post hospitalization) regarding pulmonary function tests and dyspnea score.

50 patients were enrolled in the study post hospitalization due to severe COVID 19 infection. Dyspnea score, Spirometry and 6minute walk test were performed upon discharge. Pulmonary rehabilitation program was performed. Follow up assessment of the same parameters was done 6 weeks after the program.

These results were compared with another 50 patients who were admitted in hospital due to severe COVID 19 infection but no pulmonary rehabilitation program was performed to them after hospitalization.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age range between 50 and 70 years.
  • Severe COVID infection.
  • Impaired pulmonary function tests post COVID infection.

Exclusion criteria

  • Mild or moderate COVID infection.
  • Normal pulmonary function tests post COVID infection
  • Chronic chest disease
  • End organ failure (sever heart disease-neurodegenerative disease- sever stroke)
  • Unstable angina, myocardial infarction, angioplasty, heart surgery in the previous 3 months
  • Chronic renal impairments.
  • Epistaxis, active haemoptysis
  • Recent facial, oral, or skull surgery or trauma.

Treatment and study plan

respiratory exercises - incentive spirometer - walking

Combination Product

respiratory exercises (in form of diaphragmatic breathing, pursed lip breathing exercise and incentive spirometer), rehab exercise program and walking exercise.

Primary outcomes

  1. improvement in dyspnea scale

    Time frame: 6 weeks

    modified medical research council scale (mMRC)

  2. improvement in spirometry measures

    Time frame: 6 weeks

    forced vital capacity measurement in spirometry

Secondary outcomes

  1. improvement in oxygen saturation and 6 minute walk test

    Time frame: 6 weeks

    oxygen saturation before and after 6 minute walk test

Sponsors and collaborators

Lead sponsor

Fayoum University Hospital

Other

Registry information

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jul 27, 2022
Registry last updated
Jul 27, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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