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OpenTrials
Completed

NCT Number: NCT01345487

Effect of Protein From Animal and Vegetable Sources on Appetite

New Nordic diet guidelines advocate a reduction in consumption of protein from animal sources such as beef and pork, due to environmental concerns. Instead, intake of protein from vegetable sources such as legumes and pulses should be increased. However, little is known about the effect of protein from (Nordic grown) beans and peas on body weight and appetite regulation.

The objective of this study is to examine if protein from vegetable sources (beans and peas) is comparable to protein from animal sources regarding acute meal-induced satiety.

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Key information

Conditions

Focus of Study: Appetite

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen

Frederiksberg C, 1958, Denmark

About this study

Design:

Single-blind randomized 3-way crossover meal study

Subjects:

  • 48 young healthy men (Age: 18-50 years; BMI: 19-30 kg/m2).
  • Expected completers: n=42.

End points:

  • Subjective appetite (VAS) (every 30 min for 3 hours)
  • Ad libitum energy intake (3 hours after test meal)

Experimental diets:

Iso-caloric breakfast meals (3.5 MJ) with same energy density:

A. Fava beans + Split peas (20 protein E%) B. Fava beans + Split peas + potato (10 protein E%) C. Pork/beef + potato (20 protein E%)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy men
  • 18-50 y
  • body mass index (BMI) 18.5-30.0

Exclusion criteria

  • smoking
  • participation in other studies for 4 mo prior to entry
  • weight gain/loss > 3 kg for to mo prior to entry
  • Strenuous physical activity for > 10 h/wk
  • Use of medication that can affect appetite
  • food allergies or relevance for the test meals
  • Psychiatric or metabolic disorders prohibiting participation

Treatment and study plan

Vegetable protein

Other

Vegetable protein in the form of fava beans/split peas

Animal protein

Other

Protein in the form of minced pork/beef

Primary outcomes

  1. Composite appetite score area under the curve (180 min)

    Time frame: Assessed every 30 min for 180 min after each of the three test meals which are served 1 wk apart

    Composite score calculated from 10 cm visual analogue scale ratings:

    (desire to eat + hunger + prospective food consumption + (100-fullnes) + (100-satiety))/5

  2. Ad libitum energy intake

    Time frame: Assessed 180 min after each of the 3 test meals, which are served 1 wk apart

    180 min after each test meal an ad libitum meal of spaghetti bolognese is served, and the total energy intake is recorded.

Secondary outcomes

  1. Appetite ratings

    Time frame: Assessed every 30 min for 180 min after each or the 3 test meals which are served 1 wk apart

    Assessment of hunger, fulness, satiety, desire to eat and prospective food consumption from 10 cm visual analogue scale ratings every 30 min after meal consumption for 3 hours.

Sponsors and collaborators

Lead sponsor

Arne Astrup

Other

Registry information

Acronym: PAVA

Important dates

Study start
2011
Primary completion
2011
Study completion
2011
First posted
May 2, 2011
Registry last updated
Mar 25, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.