Skip to main content
OpenTrials
Completed

NCT Number: NCT01528943

Effect of Prostacyclin on Haemostasis in Abdominal Surgery

The purpose of this study is to investigate the effect of continuous perioperative infusion of prostacyclin on haemostasis and endothelial functionality in patients undergoing major abdominal surgery.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Rigshospitalet

Copenhagen, Region Sjælland, 2100, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women above 18 years old
  • Undergoing Whipple surgery or liver resection
  • Able and willing to give informed consent

Exclusion criteria

  • Allergy towards the study medication
  • In treatment with platelet ADP receptor inhibitors or heparin (not including thrombosis prophylaxis), Factor Xa inhibitors, trombininhibitors, Vitamin K antagonists
  • Autoimmune disease
  • Intracranial bleeding within the last 6 months
  • Acute coronary syndrome or myocardial infarction within the last 6 months
  • Congestive heart disease
  • Pregnant or breastfeeding
  • Participating in another clinical study within the last 30 days
  • Liver cirrhosis
  • Need for renal replacement therapy

Treatment and study plan

Prostacycline

Drug

Continuous infusion peri -and 6 hours postoperatively of prostacycline 1 ng/kg/min

Isotonic saline

Drug

same volume as the group that are allocated to prostacycline

Primary outcomes

  1. Change in endothelial biomarkers

    Time frame: Baseline to 6 hours postoperatively

Secondary outcomes

  1. Functional haemostasis evaluated by thrombelastography

    Time frame: Baseline to 6 hours postoperatively

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Registry information

Official study title

The Effect of Prostacyclin on Haemostasis as Evaluated by Thrombelastography and Endothelial Markers in Patients Undergoing Major Abdominal Surgery. A Pilot Study

Important dates

Study start
2012
Primary completion
2013
Study completion
2014
First posted
Feb 8, 2012
Registry last updated
Mar 10, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.