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Completed

NCT Number: NCT00654290

Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft

Atrial fibrillation is the most common arrhythmia post coronary bypass surgery, currently B-blockers are the class I indication to prevent AF post CABG. We decide to evaluate use of propranolol and amiodarone separately and together to find a better prophylaxis for AF peri-CABG

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Key information

Conditions

Atrial Fibrillation Arrhythmias, Cardiac Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

45 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shiraz University of Medical Sciences/Cardiac Surgery and Cardiology Ward/Namazi and Shahid Faghihi Hospital

Shiraz, Fars, 71345, Iran

About this study

In this double blind randomized study 240 consecutive patients underwent elective coronary artery bypass grafting, being randomized prospectively into three groups, propranolol (p) (n=80), amiodarone (A) (n=80) and amiodarone with propranolol (AP) (n=80).

All groups received their medications from 7 days preoperatively and continued their medications for 5 days post CABG.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient who are going to have elective CABG
  • Signing informed consent

Exclusion criteria

  • EF<35%
  • Bradycardia<60 per min
  • Hypotension< 100 mmhg

Treatment and study plan

Amiodarone + Propranolol

Drug

Amiodarone and Propranolol 7 days pre-operation to 5 days post CABG

Amiodarone

Drug

Amiodarone treated 7 days pre-operation to 5 days post CABG

Propranolol

Drug

Propranolol from 7 days pre-operation to 5 days post CABG

Primary outcomes

  1. incidence of atrial fibrillation post CABG

    Time frame: 7 days post CABG

Secondary outcomes

  1. bradycardia, mortality, hypotension, morbidity

    Time frame: 7 days post CABG

Sponsors and collaborators

Lead sponsor

Shiraz University of Medical Sciences

Other

Registry information

Official study title

Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft, A Prospective Double-Blind Randomized Study

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Apr 7, 2008
Registry last updated
Apr 7, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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