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NCT Number: NCT07006142

Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists

The aim of this study is to determine whether a modified fasting protocol can reduce the potential risk of aspiration for patients currently prescribed GLP1-RAs.

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Key information

Conditions

Upper Endoscopy GLP1-R-related Disease

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location status: Recruiting

Location contact

Krishnan Ramanujan, MD

CONTACT

[email protected]

507-422-4898

About this study

The overall objective of this project is to identify a reasonable means by which patients on GLP1-RAs can be safely cared for in the perioperative period that can be agreed upon by all groups involved in perioperative patient care. This will be assessed in patients undergoing upper endoscopy specifically since assessment of gastric contents would be minimally invasive for this patient population receiving anesthetic care.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing elective upper endoscopy with gastroenterology team

Exclusion criteria

  • Urgent or emergent procedure
  • Inclusion of colonoscopy or antegrade small bowel enteroscopy in planned procedure
  • Upper GI barium study performed in past 24 hours.
  • Gastroparesis
  • Achalasia
  • Pancreatitis
  • Use of outpatient pro-motility medications
  • Patient refusal
  • Inability for patient to provide own consent

Treatment and study plan

Modified Fasting Guidelines

Other

Patients will follow a full-liquid diet 48 hours prior to their procedure, clear liquid diet 24 hours prior to their procedure, and nothing by mouth (NPO) after midnight on the day of their procedure

Primary outcomes

  1. Gastric contents

    Time frame: Baseline

    Number of patients who were found to have gastric contents within the stomach during the upper endoscopy.

Secondary outcomes

  1. Diagnosis of aspiration within 72 hours of procedure

    Time frame: From the time of upper endoscopy until 72 hours post-procedure.

    Whether or not a patient was diagnosed with aspiration will be determined via chart review for 72 hours after the completion of upper endoscopy. A note documenting aspiration or an ICD code associated with aspiration will indicate that this outcome occurred.

  2. Aspiration pneumonitis diagnosis postoperatively

    Time frame: 72 hours after completion of upper endoscopy

    The number of patients who have a diagnosis of aspiration pneumonitis, as identified by the presence of ICD codes J69.0 or J69.8, postoperatively.

  3. Postprocedural ICU admission

    Time frame: Immediately after upper endoscopy

    The number of patients who were admitted to the ICU immediately after upper endoscopy.

Study contacts

Contact information is provided by the study sponsor or research team.

Krishnan Ramanujan, MD

CONTACT

[email protected]

507-422-4898

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 5, 2025
Registry last updated
Jun 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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