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NCT Number: NCT07271615

Effect of Preoperative Stellate Ganglion Block on Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting

The primary objective of this study is to determine the feasibility of preoperative stellate ganglion block in reducing the incidence of postoperative atrial fibrillation in patients undergoing CABG.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • more than 18 years old
  • undergoing CABG
  • Provide informed consent

Exclusion criteria

  • History of prior cardiac surgery or atrial fibrillation ablation;
  • Emergency coronary artery bypass grafting (CABG);
  • Concomitant cardiac procedures (e.g., congenital heart disease repair, left ventricular reconstruction, valve surgery, or aortic surgery);
  • Critical preoperative status requiring mechanical or pharmacological support before CABG;
  • Left ventricular ejection fraction (LVEF) <35%;
  • History of atrial fibrillation (defined as a supraventricular tachyarrhythmia characterized by rapid and irregular atrial electrical activity);
  • Significant mitral valve disease (mitral valve area <1.5 cm² or regurgitant jet area <4 cm²), significant aortic valve disease (valve area <1.5 cm² or regurgitant jet-to-left ventricular outflow tract ratio >25%);
  • Severe left atrial enlargement (left atrial anteroposterior diameter >55 mm);
  • Poorly controlled hyperthyroidism;
  • Conditions requiring radiotherapy, chemotherapy, or long-term hormonal therapy;
  • Patients with known clinical contraindications to stellate ganglion block (SGB).

Treatment and study plan

Stellate ganglion block

Procedure

Ultrasound-guided stellate ganglion block with ropivacaine

Primary outcomes

  1. postoperative atrial fibrillation(POAF)

    Time frame: within 7 days postoperatively

Secondary outcomes

  1. cumulative time spent in postoperative atrial fibrillation

    Time frame: within 7 days postoperatively

  2. the need for antiarrhythmic medications to treat postoperative atrial fibrillation

    Time frame: within 7 days postoperatively

  3. the need for systemic anticoagulation due to postoperative atrial fibrillation

    Time frame: within 7 days postoperatively

  4. the need for postoperative electrical cardioversion

    Time frame: within 7 days postoperatively

  5. the duration of postoperative in-hospital stay

    Time frame: duration of postoperative hospital stay

  6. number of POAF

    Time frame: within 7 days postoperatively

Study contacts

Contact information is provided by the study sponsor or research team.

Chong Lei

CONTACT

[email protected]

18629011362

Sponsors and collaborators

Lead sponsor

Xijing Hospital

Other

Registry information

Official study title

Preoperative Stellate Ganglion Block Reduce the Incidence of Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: A Prospective, Randomized Controlled Pilot Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 9, 2025
Registry last updated
Dec 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.