Effect of Preoperative Pregabalin on Propofol Induction Dose

The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia. The investigators secondary issue is to test if preoperatively administered pregabalin decreases anxiety.

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Key information

Conditions

Anesthesia, General Laparoscopic Surgery

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Centre Hospitalier Universitaire de Sherbrooke

Sherbrooke, Quebec, J1H 5N4, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Laparoscopic gynaecologic surgery
Age 18-40 years
ASA class I or II
Body mass index 18-30

Exclusion criteria

Allergic to pregabalin or gabapentin
Chronic renal failure
Alcohol or drug abuse
Chronic analgesic use other than acetaminophen or NSAID
Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug
Known neurological deficiency
Suspected difficult intubation or ventilation
Atypical pseudocholinesterases

Treatment and study plan

Pregabalin

Drug

Preoperative administration of pregabalin vs placebo 1 hour before surgery

Other names: Lyrica

Primary outcomes

Propofol induction dose

Time frame: 1 hour

Evaluation of the hpreoperative pregabalin Vs placebo effect on propofol induction dose needed to induce general anesthesia assessed by entropy in gynaecologic patients undertaking minor surgical procedure.

Secondary outcomes

Preoperative anxiety

Time frame: 1 hour

Evaluation of the effect of pregabalin Vs placebo on preoperative anxiety

Sponsors and collaborators

Lead sponsor

Université de Sherbrooke

Other

Registry information

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2011
First posted: Jul 8, 2010
Registry last updated: Nov 7, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed