Effect of Prednisone onTregs and TH17

Inclusion criteria

• Diagnosis of CRS.
• A CT scan performed in the last year depicting the severity of the disease or nasal polyps on endoscopy.
• Symptomatic at the time of entry into the study as determined by scores ≥ 1.4 on the Rhinosinusitis disability index

Exclusion criteria

• Women who are pregnant or breastfeeding.
• Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study (heart, lung, kidney, diabetes, osteoporosis, cataracts, glaucoma, neurological, oncologic, liver disease or a contraindication to taking prednisone).
• Use of any other investigational agent in the last 30 days.
• Use of clinical drugs like antihistamines, leukotriene modifiers, intranasal steroids, systemic corticosteroids in the last 15 days or immunotherapy in the last year.
• Upper respiratory infection within 14 days of study start
• Smoking within the last 2 months.