Effect of Prebiotics Versus Low FODMAPs Diet on Intestinal Microbiota and Symptoms

Inclusion criteria

• Functional digestive disorder with flatulence
• Women and men between the ages of 18 and 80 years (bounds included at the inclusion visit).
• Normal body weight or with overweight (body mass index between 18.0 and 30.0 kg/m2 (bounds included)).
• Women of childbearing potential should be using or complying with one of the medically approved methods of contraception such as, but not exclusively, one of the following:

• Birth control pill
• Intra-uterine device (IUD)
• Double barrier methods (such as condoms and spermicide)
• Abstinence
• Willing to follow strict dietary instructions for the duration of the study
• Able to communicate well with the investigator and to comply with the requirements for the study.

Exclusion criteria

• Significant illness other than functional bowel disorders
• Disease/disorders which can interfere with the collection of the gas (hemorrhoids,..etc)
• Antecedents of digestive surgery, excluding appendicectomy
• Intake of antibiotics in the month (within 30 days) preceding the inclusion visit.
• Current use of any medications with potential central nervous system effects as judged by the investigator (including but not limited to antidepressants, anxiolytics, opiate pain medications)
• Taking drugs that might modify gastrointestinal function
• Change of dietary habits within the preceding 4 weeks (for instance start of a diet high in fiber) or planned change (For example to start a diet) during the period of the study