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Completed

NCT Number: NCT02967861

Effect of Pranayama on Periodontal Health

The objective of the study was to evaluate the levels of Peroxisome proliferator-activated receptor gamma (PPAR-γ), Nuclear factor-kappa B (NF-kB) and the presence of red complex microorganisms (RCM) such as Treponema denticola (T.d), Porphyromonas gingivalis (P.g) and Tannerella forsythia (T.f) in the subgingival tissues of chronic periodontitis subjects before and after intervention with pranayama as an adjunct to scaling and root planing.

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Key information

Conditions

Chronic Periodontitis Chronic Disease Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

30 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

About this study

Sixty chronic periodontitis subjects were selected out of which 30 subjects (control group) were treated with scaling and root planing (SRP) and 30 subjects (pranayama group) also underwent SRP and pranayama for 3 months. Clinical parameters were recorded and the presence of PPAR-γ, NF-kB and RCM were assessed at baseline and after 3 months

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • presence of at least 20 teeth
  • Probing pocket depth ≥ 5 mm

Exclusion criteria

  • aggressive periodontitis
  • systemic disorders
  • pregnant & lactating females
  • smokers & alcoholics
  • immunocompromised individuals

Treatment and study plan

Pranayama

Behavioral

Pranayama is the breathing exercise through the nostrils. It enhances the systemic immunity which in turn enhances the overall defense mechanism of an individual.

Scaling and Root Planing

Procedure

It is a mechanical debridement of dental plaque.

Primary outcomes

  1. Clinical efficacy of pranayama in chronic periodontitis patients from baseline to 3 months

    Time frame: 3 months

    Clinical attachment level is measured using Williams periodontal probe in millimeters with the criteria of 1 to 2 mm for slight periodontitis, 3 to 4 mm for moderate periodontits and greater or equal to 5 mm for severe periodontitis.

Secondary outcomes

  1. Microbiological efficacy of pranayama in chronic periodontitis patients from baseline to 3 months

    Time frame: 3 months

    Red complex microorganisms such as P.gingivalis, T.denticola, T.forsythia are identified as '0' for absence and '1' for presence and analysed using polymerase chain reaction from subgingival plaque samples.

  2. Efficacy of pranayama on nuclear factor-kappa B (NF-kB) in chronic periodontitis patients

    Time frame: 3 months

    The expression of NF-kB is analysed using Real time PCR after isolation of RNA from subgingival plaque samples.

  3. Efficacy of pranayama on perosxisome proliferator-activated receptor (PPAR)-γ in chronic periodontitis patients

    Time frame: 3 months

    The expression of PPAR- γ is analysed using Real time PCR after isolation of RNA from subgingival plaque samples.

Sponsors and collaborators

Lead sponsor

Meenakshi Ammal Dental College and Hospital

Other

Registry information

Official study title

Effect of Pranayama on Peroxisome Proliferator-activated Receptor Gamma, Nuclear Factor Kappa B and Red Complex Microorganisms in Patients With Chronic Periodontitis

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Nov 18, 2016
Registry last updated
Nov 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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