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NCT Number: NCT06082531

Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis

To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.

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Key information

Conditions

Platelets-rich Plasma Arthritis Cartilage Injury Joint Diseases Meniscus Disorder Musculoskeletal Diseases Osteoarthritis Osteoarthritis Knees Both Rheumatic Diseases

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint.
  • The preoperative routine tests and examinations revealed no contraindications.
  • Revised sentence: "Informed consent of the patient

Exclusion criteria

  • The platelet count or function exhibits significant abnormalities、Systemic infection transmitted through the bloodstream.
  • Prolonged usage of anti-inflammatory drugs and systemic corticoid administration.
  • In injection site or damage to the skin.
  • Patients with tumors or undergoing radiotherapy and chemotherapy.
  • Pregnant or breastfeeding women.
  • Individuals with mental illnesses who are unable to cooperate with follow-up procedures.
  • Contraindications for MRI、Patients or their families do consent to participate in the study.
  • Other circumstances that render participation in the study unsuitable.

Treatment and study plan

Sodium hyaluronate injection

Drug

The control group was injected into the joint cavity with sodium hyaluronate injection..

Primary outcomes

  1. X-ray

    Time frame: pre-operation,3 weeks after treatment, 6 months after treatment

    The postoperative plain X-ray film was utilized for the assessment of knee joint deformity, stenosis of the joint space, and hyperplasia of osteophytes.

  2. CT

    Time frame: pre-operation,3 weeks after treatment, 6 months after treatment

    The application of three-dimensional CT scan for the assessment of articular cartilage defects.

  3. MRI

    Time frame: pre-operation,3 weeks after treatment, 6 months after treatment

    The injury of ligaments, meniscus, and the knee joint was assessed using MRI.

Study contacts

Contact information is provided by the study sponsor or research team.

Yanyan Jia

CONTACT

[email protected]

+862984771794

Sponsors and collaborators

Lead sponsor

Xijing Hospital

Other

Registry information

Official study title

Therapeutic Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis and Periarticular Tissue Injury

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Oct 13, 2023
Registry last updated
Jul 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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