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Completed

NCT Number: NCT07277127

Effect of Percutaneous Electrolysis Combined With Exercise on Pain and Function in Chronic Lateral Epicondylitis

The aim of this randomized controlled trial is to compare the effects of percutaneous electrolysis combined with exercise versus exercise alone on pain and function in patients with chronic lateral epicondylitis. Participants will be randomly allocated into two parallel groups. The control group will receive a 2-week exercise program including stretching and eccentric strengthening exercises for the wrist extensor and forearm muscles. The experimental group will receive the same exercise program plus three sessions of ultrasound-guided percutaneous electrolysis applied to the extensor carpi radialis brevis tendon insertion at the lateral epicondyle (on days 1, 8, and 14). Clinical outcomes will be assessed using a 10-cm Visual Analog Scale (VAS) for pain intensity, pressure pain threshold over the common extensor tendon measured with a handheld algometer, the Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire for pain and functional disability, and the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire for upper limb function. Assessments will be performed at baseline, and then at 1 week, 1 month, and 3 months after the end of the 2-week treatment period. The study aims to determine whether adding percutaneous electrolysis to an exercise program provides greater improvement in pain and functional status than exercise alone in patients with chronic lateral epicondylitis.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sivas State Hospital

Sivas, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18 and 65 years
  • Clinically and MRI-confirmed diagnosis of chronic lateral epicondylitis (symptoms ≥ 3 months)
  • Ability and willingness to comply with the treatment protocol and follow-up schedule

Exclusion criteria

  • Previous elbow surgery or fracture in the affected limb
  • Local corticosteroid injection or other invasive treatment in the past 3 months
  • Cervical radiculopathy, systemic rheumatic disease, or other neurological disorders affecting the upper limb
  • Presence of a cardiac pacemaker or diagnosis of epilepsy
  • Pregnancy or breastfeeding
  • Serious bleeding disorder (coagulopathy) or current anticoagulant therapy
  • Inability to follow the exercise protocol or attend follow-up visits

Treatment and study plan

Exercise

Other

2-week exercise program with stretching and eccentric strengthening for wrist extensors and forearm muscles.

Percutaneous Electrolysis

Device

Participants receive the same 2-week exercise program as the control group plus three sessions of ultrasound-guided percutaneous electrolysis applied to the extensor carpi radialis brevis tendon insertion at the lateral epicondyle on days 1, 8, and 14.

Primary outcomes

  1. Change in Pain Intensity (VAS)

    Time frame: Baseline, 1 week post-treatment, 1 month, 3 months

    Pain intensity will be measured using a 10-cm Visual Analog Scale (VAS).

Secondary outcomes

  1. Change in Pressure Pain Threshold (Algometry)

    Time frame: Baseline, 1 week post-treatment, 1 month, 3 months

    Pressure pain threshold over the common extensor tendon will be measured using a handheld algometer.

  2. Change in Functional Status (PRTEE Score)

    Time frame: Baseline, 1 week post-treatment, 1 month, 3 months

    Functional disability and pain will be assessed using the Patient-Rated Tennis Elbow Evaluation (PRTEE).

  3. Change in Upper Limb Function (QuickDASH)

    Time frame: Baseline, 1 week post-treatment, 1 month, 3 months

    Upper limb disability will be evaluated using the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire.

Sponsors and collaborators

Lead sponsor

Sivas State Hospital

Other

Registry information

Official study title

Effect of Percutaneous Electrolysis Combined With Exercise on Pain and Function in Chronic Lateral Epicondylitis: A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 11, 2025
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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