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Completed

NCT Number: NCT04081155

Effect of PEEP on Lung Regional Ventilation and Perfusion

Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT

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Key information

Conditions

Mechanical Ventilation Complication Hypoxia Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Failure Respiratory Insufficiency Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Peking Union Medical College Hospital, Chinese Academy of Medical Science

Beijing, Beijing Municipality, China

About this study

  • When the research team was available, adult patients within 7days who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study.
  • Written informed consent was obtained from all patients or next of kin before data were included in the study.
  • Information collected at enrollment included demographic characteristics, such as age, sex.
  • The blood pressure（BP）,heart rate（HR）, pulse O2（SpO2）,tidal volume and lung regional ventilation and perfusion were collected at PEEP 0 centimeter H2O column and PEEP 12-15 centimeter H2O column.
  • Indicator-based EIT method: rapidly inject 10ml 10% Sodium chloride（NaCL） through central venous catheter during a 8s respiratory hold, and the curve of impedence change was collected by EIT machine

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • have been placed central venous catheter based on patient's condition
  • Under mechanically ventilation
  • Under sedation and control ventilation mode
  • Year>18

Exclusion criteria

  • Pneumothorax
  • pregnancy
  • Severe chest wall wound
  • Severe hypernatremia

Treatment and study plan

Primary outcomes

  1. lung regional ventilation distribution

    Time frame: Hour 1

    lung regional ventilation distribution measured by EIT

  2. lung regional perfusion distribution

    Time frame: Hour 1

    lung regional perfusion distribution measured by EIT

Sponsors and collaborators

Lead sponsor

Yun Long

Other

Registry information

Official study title

Effect of Positive End-expiratory Pressure(PEEP) on Regional Ventilation and Perfusion Estimated by Indicator-based Electrical Impedance Tomography(EIT) Method in Critically Ill Patients With Mechanical Ventilation

Acronym: PEEP

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Sep 9, 2019
Registry last updated
Jul 14, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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