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OpenTrials
Completed

NCT Number: NCT07622966

Effect of Osteopathic Manipulation on Circulating Immune Markers

The goal of this clinical trial is to learn if osteopathic manipulative treatment (OMT) changes levels of immune markers in healthy volunteers. The main questions it aims to answer are:

Does OMT change numbers of white blood cells or antibodies? Does OMT change levels of cytokines?

Researchers will compare volunteers treated with OMT to volunteers undergoing sham treatment to see if OMT changes levels of immune markers.

Participants will:

* complete a survey about their medical history to determine if they are healthy enough for OMT * have blood drawn * undergo either sham treatment or OMT * have blood drawn 30 minutes after treatment

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Key information

Conditions

Healthy Adult Participants Osteopathic Manipulative Treatment (OMT)

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Edward Via College of Osteopathic Medicine

Monroe, Louisiana, 71203, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • subjects are healthy; have independently read, understood, and without coercion signed the consent form; agree to allow for samples to be taken; agree to fill out all the documentation and surveys; and identifies as any race(s), ethnicity(ies), and/or gender(s)

Exclusion criteria

  • subjects present at initial visit with a fever greater than 100.5 °F; have participated in a clinical trial within the last 6 months; work night shifts; who are immunocompromised including: HIV+, have had cancers, or are pregnant or nursing; have current bone fractures of the head and neck; history of osteoporosis, acute hepatitis, deep vein thrombosis, pulmonary embolism, trauma to the liver or spleen, surgery in the past 6 months or necrotizing fasciitis. Other relative contraindications to receiving OMT include doderate to severe cardiac conditions, moderate to severe congestive heart failure, infectious mononucleosis, chronic abscesses or osteomyelitis, coagulopathies or patients on anticoagulants, COPD, and acute indurated lymph node

Treatment and study plan

Osteopathic Manipulative Treatment (OMT)

Other

Lymphatic Pump Techniques

Sham Comparator

Other

Light touch

Primary outcomes

  1. Changes in Circulating Immune Markers

    Time frame: within 30 minutes of treatment

Sponsors and collaborators

Lead sponsor

Edward Via Virginia College of Osteopathic Medicine

Other

Collaborators

  • American Osteopathic Association

Registry information

Official study title

A Molecular Approach to Examining the Immune Stimulatory Impact of Lymphatic Pump Technique in Healthy Patients; A Pilot Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 3, 2026
Registry last updated
Jun 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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