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OpenTrials
Completed

NCT Number: NCT03522896

Effect of Orange Juice on Glycemic Response

Orange juice naturally contains high concentrations of hesperidin, which affects glucose absorption in in vitro experiments. This study is to test if hesperidin and other components of orange juice (not other sugars or organic acids) affect the post-prandial blood glucose concentration derived from sugars already present in the orange juice.

Completed

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Key information

Conditions

Effect of Food on Postprandial Hyperglycemia

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Leeds

Leeds, LS29JT, United Kingdom

About this study

Healthy volunteers will consume orange juice with added water or food-grade hesperidin.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • fasting blood glucose below 5.9 mM

Exclusion criteria

  • fasting glucose above 6 mM pregnant

Treatment and study plan

Control

Other

balancing sugars and organic acids

test meal 1

Other

orange juice plus hesperidin low dose

test meal 2

Other

orange juice plus hesperidin higher dose

test meal 3

Other

diluted orange juice plus hesperidin low dose

Primary outcomes

  1. Blood glucose concentration

    Time frame: 3 hours

    iAUC/[glucose]max

Sponsors and collaborators

Lead sponsor

University of Leeds

Other

Registry information

Official study title

Effect of Hesperidin in Orange Juice on Glycemic Response in Healthy Volunteers

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
May 11, 2018
Registry last updated
Jun 28, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.