Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers

Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes. It has demonstrated that oral water remains the best hydration solution that have an effect on plasma volume expansion and cardiovascular system during exercise. While the cardiovascular effect of fluid expansion by saline serum is well known (venous return, preload and cardiac output), effect of oral water varies in the literature depending on the physiological state of the patient and the clinical state. Thus, the investigators aim to investigate oral water effects on fluid responsiveness, regional blood flow and microcirculatory changes.

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Key information

Conditions

Intravenous Fluids Fluid Challenge Fluid Responsiveness Fluid Therapy Pharmacodynamics

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Amiens-Picardie

Amiens, 80054, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy volunteer subject between 18 and 30 years old
patient with a regular sinus rhythm
Echogenic subject.
Fasting of solid and liquid since 8 h
Subject in regular sinus rhythm.
Written consent signed.

Exclusion criteria

Any known cardiac, renal or endocrine pathology.
Arrhythmia rhythm disorder by atrial fibrillation
Pregnant or nursing woman.
Pathology versus indicating Nacl administration.
Person under tutors or curators or deprived of liberty.
Person not affiliated to a social security scheme.

Treatment and study plan

saline intravenous administration

Other

Administration of 500 mL of saline (NaCl 0.9%) administered by the venous route

Oral water

Other

500 ml oral water

Primary outcomes

number of fluid responders 30 minutes after fluid expansion

Time frame: 30 minutes after fluid expansion

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: WATERNAL

Important dates

Study start: 2021
Primary completion: 2023
Study completion: 2023
First posted: Dec 10, 2021
Registry last updated: May 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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