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Completed

NCT Number: NCT03505684

Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women

Comparison of a randomized, double-blind, and control-group study for the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants

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Key information

Conditions

Skin Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin Wrinkling

Age range

40 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Integrated Research Institute for Natural Ingredients and Functional Foods

Yangsan, 50612, South Korea

About this study

The aim is to investigate the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants by a randomized, double-blind, and control-group study.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • > = 4 of Tewameter

Exclusion criteria

  • Within the last 6 months, took skin surgery including cosmetic purpose
  • Diabetic patients with poor glycemic control with a fasting blood glucose of 160 mg/dl or more
  • Creatinine levels: more than twice the normal upper limit
  • AST (GOT) or ALT (GPT) levels: more than twice the normal upper limit
  • Uncontrolled hypertension
  • sun allergy or sensitive skin
  • functional cosmetics that affect dermal moistures and wrinkles within the last 3 months.
  • If you have participated or are planning to participate in another clinical trial within the past month
  • Alcohol abuser
  • If they are pregnant or lactating or have a pregnancy plan during the clinical trial Those with allergic reactions to the constituent food
  • Any person deemed inappropriate by the researcher for other reasons

Treatment and study plan

CTP

Dietary Supplement

1,000 mg of CTP was orally administered per day for 12 weeks.

placebo (starch)

Dietary Supplement

placebo (starch)

Primary outcomes

  1. changes in Transepidermal Waterloss by Tewameter

    Time frame: baseline, after 6 weeks, and after 12 weeks

    comparison between baseline, after 6 weeks, and after 12 weeks

Secondary outcomes

  1. changes in skin wrinkling indices by Visiometer

    Time frame: baseline, after 6 weeks, and after 12 weeks

    comparison between baseline, after 6 weeks, and after 12 weeks

  2. skin elasticity by Cutometer

    Time frame: baseline, after 6 weeks, and after 12 weeks

    comparison between baseline, after 6 weeks, and after 12 weeks

  3. changes in hydration level of the skin surface by Corneometer

    Time frame: baseline, after 6 weeks, and after 12 weeks

    comparison between baseline, after 6 weeks, and after 12 weeks

Sponsors and collaborators

Lead sponsor

Pusan National University Yangsan Hospital

Other

Registry information

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Apr 23, 2018
Registry last updated
Aug 28, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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