Effect of Oral Administration of a Herbarium Mixture (Guazuma Ulmifolia and Tecoma Stans) on Metabolic Profile in Type 2 Diabetic Patients

A randomized, double blind, placebo controlled, clinical trial was carried out 40 type 2 diabetic patients independently of their basal hypoglycemic treatment. At beginning and at end of the study, BMI, waist circumference, a metabolic profile (fasting glucose, HbA1c, lipids and biosecurity profile), were measured. The patients were randomly assigned to receive the herbarium mixture (GU/TS) 1 g before each meal, or placebo for a period of 90 days. All patients received therapy medical nutrition.

Inclusion criteria

• Signing of letter of consent under written information.
• Men and women with serum glucose of ≥126 and <400 mg / dl and / or HbA1c ≥6.5% and <10%.
• Age between 30 and 60 years.
• BMI between 25 - 39.9 kg / m2.
• With or without pharmacological treatment with oral hypoglycemic agents or insulin
• Stable body weight during the last 3 months (± 5%).
• Women in the follicular phase of the menstrual cycle (days 3 to 8 of the cycle) at the time of the laboratory tests
• Women who do not expect to be pregnant within the next 3 months.

Exclusion criteria

• Physical or mental incapacity that makes it impossible to carry out the intervention.
• Uncontrolled thyroid disease
• Women with suspicion or confirmation of pregnancy.
• Women who are breastfeeding.
• Hepatic disease or elevation to double the upper normal value of TGO and TGP.
• Diagnosis of renal insufficiency or creatinine> 1.5 mg / dL or glomerular filtration rate <60 mL / min).
• Known hypersensitivity to calcined magnesia or Guazuma ulmifolia and / or Tecoma stans.