Effect of Oleactiv® on LDL Oxidability

Inclusion criteria

• Male aged between 40 and 70 years (limits included),
• BMI between 20 and 30 kg / m² (limits included)
• Weight over 65kg (to respect volume blood collection reglementation)
• Fasting plasma LDL cholesterol between 1.16 g / L and 1.9 g / L (limits included) if the cardiovascular risk is low OR Fasting plasma LDL cholesterol between 1.0 g / L and 1.9 g / L (limits included) if the cardiovascular risk is moderate (SCORE calculated according to the European Society of Cardiology 2019)
• Able and willing to participate to the study by complying with the protocol procedures as evidenced by his dated and signed informed consent form,
• Affiliated with a social security scheme.

Exclusion criteria

• Dyslipidemia or hyperlipidemia:

• Fasting total cholesterol ≥ 3.0 g / L
• Fasting triglycerides> 2 g / L
• with heterozygous familial hypercholesterolemia
• Hypertensive-treated
• Diabetes treated or not with medication
• Taking drugs known to have an impact on lipid metabolism (statin, ezetimibe, colestyramine, fibrate, etc.) in the month preceding inclusion and / or likely to consume them during the test
• Consuming food supplements or functional foods known to have an influence on cholesterolemia (phytosterol, phytostanol, red rice yeast, policosanols, beta-glucans at a dose greater than 3 g / d) in the month preceding the inclusion and / or likely to take during the test
• Consuming probiotics in the form of a food supplement in the month preceding inclusion and / or likely to take them during the test
• Following or having followed a hypocaloric diet (energy intake <1,500 kCal / day) in the month preceding inclusion and / or likely to undertake this diet during the test
• Who donated blood in the 3 months preceding inclusion
• Diagnosed eating disorders (bulimia, anorexia nervosa, vomiting)
• High level athlete (physical activity for 1 hour per day)
• Smoking more than 5 cigarettes per day
• Bariatric surgery or who has a gastroplasty ring
• Consuming more than 3 standard drinks of alcoholic beverage daily,
• Consuming drugs,
• Suffering from serious illnesses such as cancer, recent myocardial infarction, serious digestive pathologies or others diseases found to be inconsistent with the conduct of the study by the investigator,
• Taking part in another clinical trial or being in the exclusion period of a previous clinical trial,
• Under legal protection (guardianship, wardship) or deprived from his rights following administrative or judicial decision,
• Presenting a psychological or linguistic incapability to sign the informed consent,
• Any other condition which in the investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject.
• Known allergy to one of the component of the supplement (Grape, olive, artichoke, blackcurrant or pomegranate) or to corn.