Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome

Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise testing in patients with OSA. The investigators hypothesis is that patients with overlap syndrome will have a greater improvement in their cardiopulmonary exercise testing besides a possible improvement in their lung function test and airway resistance.

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Key information

Conditions

Obstructive Sleep Apnea Apnea Chronic Disease Chronic Obstructive Pulmonary Disease Disease Attributes Dyssomnias Lung Diseases Lung Diseases, Obstructive Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

OU Medical Center, Oklahoma City, Oklahoma, United States

About this study

Patients presenting to the Oklahoma City VA sleep clinic with obstructive sleep apnea syndrome and a desire to initiate CPAP treatment will be included if they have overlap syndrome. Patients will undergo a spirometry and CPET before being started on CPAP as part of standard clinical care. The CPET will be repeated after 8-12 weeks of CPAP use. Patients will be excluded if they have any contraindication to mild exercise or they cannot perform an exercise test due to limited mobility.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Obstructive sleep apnea (OSA)
COPD

Exclusion criteria

Inability to perform exercise test due to musculoskeletal limitation
Cardiac condition preventing patient from mild exercise
Continuous oxygen supplement

Treatment and study plan

CPET

Diagnostic Test

CPET will be done on patients with overlap syndrome before and after clinical CPAP treatment.

Primary outcomes

Efficacy of nasal CPAP on CPET performance in patients with overlap syndrome

Time frame: 2 years

Sponsors and collaborators

Lead sponsor

University of Oklahoma

Other

Registry information

Official study title

Effect of Continuous Positive Airway Pressure (CPAP) and Cardiopulmonary Exercise Testing(CPET) in Patient With Obstructive Sleep Apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD)

Important dates

Study start: 2009
Primary completion: 2014
Study completion: 2014
First posted: Dec 16, 2009
Registry last updated: Apr 14, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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