Effect of N_Acetylcysteine on Liver Functions in Donors in Living Liver Transplantation

our practice for the past 10 years we have noticed a transitional impairment of liver function (elevated liver enzymes, total and direct bilirubin, and elevated serum lactate levels) following donors' liver resection. Several drugs have been investigation on liver regeneration , proven benefit of N-Acetylcysteine (NAC) on rats with steatohpatitis

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Key information

Conditions

Liver Transplant; Complications

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Faculty of medicine

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ASA I or II donors
healthy adult

Exclusion criteria

kidney, liver disease
any contraindications for organ donation

Treatment and study plan

N-Acetylecysteine

Drug

N-Acetylecysteine 150 mg/kg diluted in 100 ml glucose 5 % over 40 minutes followed by NAC 12.5 mg/kg in 500 ml glucose 5% over 4 hours, followed by NAC 6.25 mg/kg for 2 postoperative days

Placebo

Drug

Ringer acetate continuous infusion at the same rate for 2 days.

Primary outcomes

Serum lactate

Time frame: 24 hours postoperative

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Effect of N_Acetylcysteine on Liver Functions in Donors in Living Donor Liver Transplantation

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Aug 16, 2018
Registry last updated: Feb 5, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed