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NCT Number: NCT05537467

Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients

The study aims to assess the effect of music on the heart resulting in a change in their exercise capacity among systolic heart failure patients undergoing Cardiopulmonary Exercise testing.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Studies have previously shown the positive impact of music on the autonomic nervous system, neurohormonal and cardiovascular system. In addition, a previously published study found a positive impact of music resulting in an improvement of quality of life (QOL) in heart failure patients. Proposed mechanisms of benefit of music in heart failure include a reduction in sympathetic activity, and modulation of parasympathetic activity. Further, reduction in anxiety and arterial relaxation are thought to be beneficial effects of music. It is hypothesized that heart failure patients listening to music would have better exercise stress test performance and increased exercise time.

Adult patients with systolic heart failure scheduled to undergo Cardiopulmonary Exercise (CPX) testing at the Gill Heart and Vascular Institute will be recruited.

While the patients are undergoing Cardiopulmonary exercise testing, patients randomized to the 'music arm' will listen to pre-selected upbeat music during their duration of the exercise testing via headphones that will be provided to patients by the study personnel. The patients who are randomized to 'non-music arm' in which their headphones will not play music and the patients will perform the cardiopulmonary exercise testing as usual.

Standard clinical care is performing cardiopulmonary exercise testing without any music.

The investigators will then compare the results of CPX study of the two arms to assess the impact of music on exercise performance.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (age >18 years)
  • Able to consent
  • English speaking

Exclusion criteria

  • Severe hearing deficiency
  • Unable to exercise.

Treatment and study plan

Music

Other

Patients randomized to the music group will listen to upbeat music using headphones.

Primary outcomes

  1. Difference in O2 consumption (VO2) [L/min]

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm.

  2. Difference in CO2 production (VCO2) [L/min]

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm.

  3. Difference in respiratory exchange ratio (RER)

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm.

  4. Difference in Minute Ventilation (VE) [L/min]

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm

  5. Difference in Ventilatory Threshold (VT) [L]

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm

  6. Difference in respiratory rate (RR) [Breaths per minute]

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm

  7. Difference in Ventilatory Equivalent of CO2 (VE/VCO2)

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm

Secondary outcomes

  1. Difference in Heart Rate [Beats per minute]

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm

  2. Difference in O2 Pulse [ml]

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm

  3. Difference in Systolic and Diastolic Blood Pressure [mmHg]

    Time frame: 15 minutes (at baseline 8 breaths, Anaerobic Threshold 8 breaths, Peak 8 Breaths)

    Assess above performance parameters in CPX and compare between Music and Non-Music arm

  4. Difference in Exercise time [mm:ss]

    Time frame: 15 minutes (Start to end of CPX study)

    Compare the CPX parameter between Music and Non-Music Arm

  5. Difference in Work rate [watt]

    Time frame: 15 minutes (Start to end of each CPX study)

    Compare the CPX parameter between Music and Non-Music Arm

Study contacts

Contact information is provided by the study sponsor or research team.

Jennifer R Isaacs, MS, MS

CONTACT

[email protected]

859-323-4738

Peggy J Hardesty, APRN, MSN

CONTACT

[email protected]

859-323-0295

Sponsors and collaborators

Lead sponsor

Maya Ignaszewski

Other

Registry information

Acronym: MUSIC-CPX

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Sep 13, 2022
Registry last updated
Jan 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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