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Completed

NCT Number: NCT03094377

Effect of Multisensory Stimulation on Upper Extremity Motor Recovery in Stroke Patient: a Preliminary Testing

Despite the advances in stroke rehabilitation, post-stroke upper extremity impairment is still a major challenge. Increasing evidence can be found supporting stimulation of the afferent receptor enhances neuroplasticity in the brain. Studies have suggested multisensory stimulation could promote motor learning by re-establishing the disrupted sensorimotor loop due to stroke and enhance neuroplasticity.

The objective of the study was to examine the effect of multisensory stimulation on upper-extremity motor recovery and self-care function in stroke patients.

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Key information

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wong Tai Sin Hospital

Wong Tai Sin, Hong Kong

About this study

Stroke patients referred to occupational therapy division of geriatric day hospital will be recruited and randomly assigned to a multisensory therapy group or a conventional training group. The Multisensory therapy group received 12 weeks (two sessions/ week; 90 minutes/session) training. Each session began with 15 minutes of sensory stimulation (cold and vibration), 45 minutes of motor training and 30 minutes of self-care training. The conventional training group included 12 weeks (two sessions/ week; 90 minutes/session) training. Each session included 60 minutes of upper extremity motor practice and 30 minutes of self-care training.

Outcome measures included: Brunnstrom's stage, Fugl-Meyer Assessment Scale and Functional Test for the Hemiplegic Upper Extremity were used for upper limb motor control and function; and Manual muscle testing was used for muscle strength. The modified Barthel Index was used for self-care performance

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • First-time ischemic or hemorrhagic stroke;
  • Stroke onset > 4 weeks and < 6 months
  • Single lesion
  • Upper extremity motor deficit
  • No severe cognitive impairment and able to follow verbal instructions.

Exclusion criteria

  • Skin conditions/ injuries over the stimulation application areas
  • Contraindication for cold or vibration application
  • Speech disorder or global aphasia
  • Musculoskeletal or cardiac disorders
  • Other neurological conditions
  • History of diabetes or sensory impairment attributable to peripheral vascular disease or neuropathy

Treatment and study plan

Multisensory therapy

Other

Sensory stimulation, motor training and ADL training

Conventional training

Other

Motor training and ADL training

Primary outcomes

  1. Change from baseline Fugl-Meyer Assessment of Motor Recovery at 3 months

    Time frame: Baseline and post intervention at week 12

    The Fugl-Meyer Assessment was used to assess the progress in synergistic and voluntary movement at baseline and post intervention.

  2. Change from baseline Functional Test for the Hemiplegic Upper Extremity at 3 months

    Time frame: Baseline and post intervention at week 12

    The Functional Test for the Hemiplegic Upper Extremity was used to evaluate the recovery of the hemiplegic upper extremity functions at baseline and post intervention.

Secondary outcomes

  1. Change from baseline Modified Barthel Index at 3 months

    Time frame: Baseline and post intervention at week 12

    The Modified Barthel Index was used to measure functional performance in basic activities of daily living at baseline and post intervention.

  2. Change from baseline Manual Muscle testing at 3 months

    Time frame: Baseline and post intervention at week 12

    Manual muscle testing (MMT) was used for the evaluation of the motor recovery and strength of upper extremity muscle groups at baseline and post intervention.

Sponsors and collaborators

Lead sponsor

Tung Wah College

Other

Registry information

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Mar 29, 2017
Registry last updated
Mar 29, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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