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Completed

NCT Number: NCT07042464

Effect of Modified Poco-Poco Exercise to Aging Biomarkers in Elderly

Subject with sarcopenia get modified poco-poco exercise program for 12 weeks

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Key information

Conditions

Geriatrics Rehabilitation

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hasan Sadikin General Hospital

Bandung, Indonesia

About this study

34 participants (>60 years) with sarcopenia were modified poco-poco exercises three times weekly for 12 weeks will assessed sarcopenia staging (determined by assessing skeletal muscle index, muscle strength, physical performance) and levels of global DNA methylation and GDF-15.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age above 60 years old
  • Have sarcopenia (based on AWGSOP 2019 criteria)

Exclusion criteria

  • Hearing impairment/loss hindering participants to receive verbal instructions
  • Vision impairment/loss hindering participants to receive instructions
  • Musculoskeletal impairment or severe joint diseases (i.e. deformity in Osteoarthritis or Rheumatoid Arthritis)
  • Participants have been involved in other exercise program
  • Severe cardiovascular disease diagnosed by Cardiologist.
  • Participants will be excluded from the research if they skip 3 sessions of the program consecutively or skip 5 sessions cumulatively

Treatment and study plan

Modified poco-poco exercises

Procedure

Participants performed modified poco-poco exercises three times weekly for 12 weeks

Primary outcomes

  1. Sarcopenia Staging (Skeletal Muscle Index)

    Time frame: 12 weeks

    Skeletal muscle index

  2. Sarcopenia Staging (Muscle Strength)

    Time frame: 12 weeks

    Hand Grip Strength, score in kilograms

  3. Sarcopenia Staging (Physical Performance)

    Time frame: 12 weeks

    Short Physical Performance Battery, score in numerical 0-12

  4. Levels of Global DNA Methylation

    Time frame: 12 weeks

    Global DNA methylation levels were analyzed using the ELISA-based kit

  5. Levels of Growth Differentiation Factor 15

    Time frame: 12 weeks

    Growth Differentiation Factor 15 were analyzed the Quantikine ELISA Human GDF-15 Immunoassay

Sponsors and collaborators

Lead sponsor

Universitas Padjadjaran

Other

Registry information

Official study title

Effect of Modified Poco-Poco Exercise to Global DNA Methylation, Growth Differentiation Factor-15, and Sarcopenia Staging in Elderly

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 29, 2025
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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