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Completed

NCT Number: NCT01018277

Effect of Mobilization on Acute Postoperative Pain and Nociceptive Function

Aim of the present study is twofold.

* First we want to evaluate the effect of mobilization on acute postoperative pain * Second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty

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Key information

Conditions

Pain, Postoperative Neurologic Manifestations Pain Pain Sensitivity, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hvidovre University Hospital

Copenhagen, Hvidovre, Denmark

About this study

Little is known about the effect of mobilization on acute postoperative pain and mobilization induced pain, and if altered pain sensitivity occur under these circumstances.

  • First we want to evaluate the effect of mobilization on acute postoperative pain using the visual analog scale (VAS)
  • Second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty, using two simple tools, the Pain Matcher and a Pressure Algometer.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled for total unilateral knee arthroplasty

Exclusion criteria

  • Cognitive dysfunction or peripheral / central neurological dysfunction inconsistent with protocol completing
  • Alcohol and medical abuse (as defined by the National Health Service of Denmark
  • Daily use of opioids or glucocorticoids

Treatment and study plan

Mobilization (walking)

Other

25 meters twice

Primary outcomes

  1. Pain score on the visual analog scale (difference before and after two mobilisation seances)

    Time frame: up to 24 hours

    pain at rest (supine) 5 min after exercise(after the 2nd walk)

Secondary outcomes

  1. Pain score on the visual analog scale (difference before and after two mobilisation seances)

    Time frame: up to 24 hours

    pain at rest (supine) 20 min after the 2nd walk, pain during passive hip flexion and pain during passive knee flexion 5 and 20 min after the 2nd walk, as well as pain during the 2nd walk after 6 and 25 m

  2. Pain sensitivity measured with pressure algometry and with pain matcher (difference before and after two mobilisation seances and difference before and after surgery)

    Time frame: up to 24 hours

    Nociceptive function before and after postoperative exercise

Sponsors and collaborators

Lead sponsor

Hvidovre University Hospital

Other

Collaborators

  • Lundbeck Foundation

Registry information

Official study title

Effect of Mobilization on Acute Postoperative Pain and Nociceptive Function After Total Knee Arthroplasty: A Prospective, Consecutive, Trial

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Nov 23, 2009
Registry last updated
Apr 20, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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