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NCT Number: NCT07056933

Effect of Minoxidil Solution Iontophoresis on Androgenic Alopecia

The aim of the study is to evaluate the therapeutic efficiency of minoxidil solution iontophoresis on Androgenic Alopecia.

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Key information

Conditions

Alopecia Hair Diseases Hypotrichosis Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Mahmoud Ibrahim Mohamed

Zagazig, Egypt

About this study

Hair is an important component of identity and self-image. Hair loss can lead to a variety of psychological difficulties and have a negative impact on quality of life (QoL). Loss of self-confidence lowered self-esteem, and heightened self-consciousness are common responses to hair loss, particularly for women. People with alopecia are more likely to develop depression and anxiety.

Some studies have proposed iontophoresis and ultrasound as energetic drug delivery methods to favor topical therapy of alopecia. Iontophoresis is a non-invasive technique that applies a small electric current (of no more than 0.5 mA/cm2) on the skin's surface to increase and control drug delivery. The technique is widely studied to stimulate the skin penetration and permeation of hydrophilic drugs, which would not be absorbed by the skin when passively applied. The transport of drugs through the skin as a result of the electric current is driven by two different mechanisms, ie, electromigration in the case of charged drugs and electroosmosis in the case of neutral drugs.

Furthermore the need of this study is developed from the lack in quantitative knowledge and information in published studies which investigate effect of minoxidil solution iontophoresis on Androgenic alopecia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Twenty-five adult aged 18-65 with diagnosed androgenic alopecia.
  • They diagnosed as Androgenic alopeacia by their physicians and referred for physical therapy management.
  • Medically and psychologically stable patients.

Exclusion criteria

  • History of hypersensitivity to minoxidil solution or Intophoresis.
  • Scalp infection
  • Concurrent hair loss treatments.
  • Patients who suffer from hypertrophic and/or keloidal scars and a skin condition in the area of Androgenic alopecia that would interfere with study procedures.
  • plaque psoriasis, tattoo, birthmark, facial hair.
  • Patients with medical red flags as severe psychiatric disorder or cognitive deficits.
  • Medically unstable and uncooperative patients.
  • Immunocompromised status.
  • History of skin cancer.
  • Recurrent herpes viral infection.
  • Pregnancy or breastfeeding status.

Treatment and study plan

Minoxidil solution iontophoresis

Other

The half of the scalp of the participants will be treated with 5% minoxidil solution through Iontophoresis that will be applied at small low voltage (typically 10 V or less) continuous constant current (typically 0.5 mA/cm2 or less) to push a charged drug into skin or other tissue, twice daily at home.

saline solution iontophoresis

Other

The other half of the scalp of the participants will be treated with placebo saline solution ( control) with the current application.

Primary outcomes

  1. Change in the number of hair follicles

    Time frame: 12 weeks

    Trichoscopy will be used to detect the change in the number of hair follicles as a comparison between before and after intervention. Trichoscopy helped with the definitive diagnosis of Alopeacia in patients for whom the clinical diagnosis was doubtful, which was confirmed by histopathology. Thus trichoscopy is a noninvasive, sensitive and specific investigation that is valuable in women with alopecia, the cause of which is otherwise very difficult to assess clinically, and it has a definite role in the diagnosis of cases with an atypical clinical picture.Trichoscopy results were obtained in frontal, occipital and both temporal areas of scalp, including number of yellow dots and vellus hairs, number of hairs in one pilosebaceous unit and percentage of follicular ostia with perifollicular hyperpigmentation.

Secondary outcomes

  1. Change of hair thickness

    Time frame: 12 weeks

    Global Photographic System will be used to detect the change of hair thickness as a comparison between before and after intervention.

    The Global Photographic Assessment is useful for determining overall clinical changes in a patient over times period in a standardized manner, Global Photographs are head shots taken a short distance away from the patients, a patient is usually photographed from the front, top, sides, and back to show accordingly a frontal hair line, crown, partition and vertex.

Study contacts

Contact information is provided by the study sponsor or research team.

Doaa Aly, PHD

CONTACT

[email protected]

0112466339

Mahmoud Ahmed, Master

CONTACT

[email protected]

0121223877

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 9, 2025
Registry last updated
Jul 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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