Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty

Inclusion criteria

• Persons 65 years of age or older who have been operated on for the first time for total knee arthroplasty,
• who are undergoing an outpatient rehabilitation program according to standard clinical practice,
• who sign the informed consent form.

Exclusion criteria

• Chronic renal disease at stage G3b or higher or glomerular filtration rate <30 ml/min/1.73m2.
• Hepatic insufficiency, cirrhosis.
• Neuromuscular and neurodegenerative diseases (amyotrophic lateral sclerosis, multiple sclerosis, muscular dystrophy, myasthenia gravis, Parkinson's disease, etc.).
• Severe or very severe chronic obstructive pulmonary disease (COPD) (GOLD III-IV).
• Moderate or severe chronic heart failure (NYHA 3-4).
• Central sensitivity syndrome (fibromyalgia and chronic fatigue syndrome).
• Moderate or severe cognitive impairment (GDS≥4).
• Moderate-severe dependence for basic activities of daily living (preintervention Barthel index <60 points).
• Hemiparesis, amputation or malformation of any limb.
• Consumption of creatine monohydrate supplements in the last 6 months.