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Completed

NCT Number: NCT00538707

Effect of Mental Stress on Platelet Function

The aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages

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Key information

Conditions

Mental Stress Behavior Behavioral Symptoms Stress, Psychological

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital of Zurich

Zurich, Switzerland

About this study

Psychological stress is an important cardiovascular risk factor. Activation of platelets plays an important role in atherosclerosis development and it could be one of the mechanisms linking psychological stress and cardiovascular diseases.

We plan to include 32 healthy subjects. (16 in every group). One group with subjects at age 20 - 49 and the other group with subjects at age 50 - 70 years.

The aim of the study will be to assess the acute and chronic effect of a standard short mental stress (2-minute Bondet Test) on platelet function and of the level of endothelin-1, catecholamines and cortisol. We plan to evaluate if age may play a role in the effect of psychological stress on platelet function.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy subjects between 20 - 70 years of age
  • written informed consent
  • no evidence of diseases

Exclusion criteria

  • pregnancy
  • oral contraceptives
  • smoking
  • use of aspirin or NSAIDs within the last week
  • use of benzodiazepines within the last week
  • Alcohol or drug abuse
  • participation in another study within the last month

Treatment and study plan

2-minute Bondet test

Behavioral

2-minute Bondet test

Other names: 2-minute Bondet light test

Primary outcomes

  1. Evaluation of platelet function (shear stress dependent platelet adhesion and aggregation) before and after mental stress

    Time frame: 60 minutes

Secondary outcomes

  1. Evaluation of the plasma level of endothelin, catecholamines and salivary cortisol level before and after mental stress

    Time frame: 60 minutes

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Official study title

Effect of Mental Stress on Platelet Function in Healthy Subjects

Important dates

Study start
2007
Primary completion
2009
Study completion
2009
First posted
Oct 3, 2007
Registry last updated
Feb 10, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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