Effect of Melatonin Patches on Sleep in Urological Surgery

Patients undergoing urological surgery may experience a decrease in sleep quality due to many factors such as hospitalization, different environment, pain, stress and anesthesia. After surgery, melatonin secretion decreases and circadian rhythm becomes irregular in patients. This problem can lead to sleep disorders in patients. Melatonin is an important hormone that regulates both sleep and circadian rhythms. The aim of this study is to observe the effect of a melatonin skin patch designed to produce melatonin in a way that ensures a stable increase in melatonin levels in the blood, on patients undergoing urological surgery.

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Key information

Conditions

Urological Surgery Dyssomnias Mental Disorders Nervous System Diseases Sleep Disorders, Intrinsic Sleep Initiation and Maintenance Disorders Sleep Wake Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Atlas University

Istanbul, Turkey (Türkiye)

About this study

The purpose of this study was to observe the effect of a melatonin skin patch designed to produce melatonin, which would provide a stable increase in blood melatonin levels, on patients undergoing urological surgery. The patients were applied a melatonin patch before surgery. The other group received routine nursing care.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who have undergone planned urological surgery,

Those who receive melatonin patch therapy,
Those who are between the ages of 18-70,
Those whose hemodynamic conditions are stable will be included.

Exclusion criteria

•Patients who used different sleeping pills/hypnotics during the study period,

Patients with delirium/psychiatric illness,
Patients with hearing and speech problems will not be included.

Treatment and study plan

A skin patch (2.1 mg melatonin) was applied to the melatonin group. The melatonin patches will be placed at 8:00 PM (on the upper chest or forearm, as determined by the patient) before going to sleep

Other

A skin patch (2.1 mg melatonin) was applied to the melatonin group.

Primary outcomes

sleep quality

Time frame: The Richards-Campbell Sleep Scale will be completed at 20:00 the evening before surgery and at 06:00 the morning of surgery.

Sleep is examined in the parameter and scored between 100 'very suitable' and 0 'not suitable'. The higher the score obtained from the scale, the higher the patient's sleep quality is considered.

Sponsors and collaborators

Lead sponsor

Atlas University

Other

Registry information

Official study title

Effect of Melatonin Patches on Sleep Quality in Patients Undergoing Urological Surgery

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Apr 4, 2025
Registry last updated: Nov 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed