Effect of Mediterranean Diet in Obese Adolescents With Nonalcoholic Fatty Liver Disease

This study was conducted to evaluate the effect of Mediterranean and low-fat diet on hepatic fat, inflammation and oxidative stress in obese adolescents with nonalcoholic fatty liver disease (NAFLD). The study, which was designed as a single blind randomized control, was completed with 44 obese adolescents diagnosed with NAFLD between the ages of 11-18. Adolescents were randomized to either a Mediterranean diet (n = 22) or a low-fat diet (control diet) (n = 22) for 12 weeks. At the beginning of the study and at the 12th week, adolescents' blood samples, physical activity and food consumption records were taken, anthropometric measurements and body composition analyzes were made, and antioxidant food consumption frequency and Mediterranean diet quality index questionnaire were applied to adolescents. In the controls performed at the 2th, 4th, 6th, 8th, and 10th weeks, the physical activity and food consumption records of the adolescents were repeated and anthropometric measurements and body composition analyzes were made again.

Inclusion criteria

• Being between the ages of 11-18
• Being obese (BMI ≥95.persentil)
• Getting a diagnosis of Grade≥1 NAFLD

Exclusion criteria

• Existence of liver disease (wilson,hepatitis etc.) other than NAFLD
• Drinking alcohol
• Having a history of type 1 and type 2 diabetes
• Using drugs that can cause steatosis
• Using lipid-lowering drugs
• Using weight loss medications
• Having applied dietary therapy for any disease and weight loss
• Existence of a chronic inflammatory disease
• Existence of cancer
• Thyroid dysfunction (hyperthyroid and hypothyroidism)
• Existence of a history of hepatic virus infection
• Having a history of parenteral nutrition
• Being pregnant and breastfeeding
• Receiving antibiotic treatment within 3 months prior to the study
• Regularly consuming foods containing probiotic and prebiotic properties and / or using nutritional supplements