Effect of Meal Patterning on Carotenoid Absorption From Vegetables

The purpose of this research study is to determine how different meal patterns influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The hypothesis is that carotenoid absorption will be lower when daily vegetables are consumed in one meal compared two smaller meals throughout the day.

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Key information

Conditions

Carotenoid Bioavailability Dietary Modification

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age range: 18-50 years
Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m²
Weight stable (<4.5 kg change within the last 3 months)
Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months
Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl)
Non-smoking
Non-diabetic
No current use of medication affecting lipid profile
No intestinal disorders including lipid malabsorption, lactose intolerance
No heavy consumption of alcohol (>2 drinks per day)
No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study

Exclusion criteria

Diabetic
Use of lipid altering medications

Treatment and study plan

Meal Pattern Treatment A

Other

In treatment A, subjects consumed 100% of salad vegetables and canola oil in the first meal and 0% in the second. Additional protein-rich "chef's salad" ingredients were distributed equally between meals.

Meal Pattern Treatment B

Other

In treatment B, subjects consumed 50% of salad vegetables and canola oil in the first meal and 50% in the second. Additional protein-rich "chef's salad" ingredients were distributed equally between meals.

Meal Pattern Treatment C

Other

In treatment C, subjects consumed 75% of vegetables and oil in the first meal and 25% in the second. Additional protein-rich "chef's salad" ingredients were distributed equally between meals.

Primary outcomes

Area under the concentration (AUC) vs time curve for carotenoids in the triglyceride-rich lipoprotein (TRL) fraction of plasma.

Time frame: 0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12 hours post dose

Sponsors and collaborators

Lead sponsor

Purdue University

Other

Registry information

Acronym: S26

Important dates

Study start: 2011
Primary completion: 2011
Study completion: 2011
First posted: May 17, 2013
Registry last updated: May 17, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed