Effect of Mannitol on Postreperfusion Syndrome During Living Donor Liver Transplant

Postreperfusion syndrome during living liver transplants remains a serious concern for transplant anesthesiologists. This syndrome is responsible for decreases in systemic blood pressure, systemic vascular resistance, and cardiac output and can even lead to cardiac arrest. Delayed graft function and primary graft nonfunction are closely related to postreperfusion syndrome (Therefore, attenuating the syndrome during anesthesia is of great importance.

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Key information

Conditions

Liver Transplant Disorder

Age range

16 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Medicine Ain Shams University

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with end-stage liver disease who will undergo living donor transplantation.

Exclusion criteria

Patients with a history of portopulmonary hypertension.
Hepatopulmonary syndrome.
Cirrhotic cardiomyopathy.
Hepatorenal syndrome types 1 and 2.

Treatment and study plan

Mannitol

Drug

During the anhepatic phase, the patients in the mannitol group (30) will receive 1 g/kg

0.9% normal saline

Other

the same amount of 0.9% normal saline

Primary outcomes

mean arterial blood pressure

Time frame: one hour after reperfusion

postreperfusion mean blood pressure

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Effect of Mannitol on Postreperfusion Syndrome During Living Donor Liver Transplant: a Randomized Clinical Trial

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2022
First posted: Mar 14, 2022
Registry last updated: Jan 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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