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NCT Number: NCT02493556

Effect of Low-level Laser Therapy on Exercise-induced Muscle Damage

Introduction: The effects of Low Level Laser Therapy (LLLT) on exercise-induced muscular damage have been studied over the last years. Studies have been conducted on animals and humans in order to try to show the benefits of the intervention, but there is still conflicting evidence about its protective and therapeutic effects.

Objectives: To describe the effects of LLLT on pain, strength and muscular inflammation after plyometric exercise.

Methods: A randomized, double-blinded, placebo-controlled trial with participation of 20 male healthy volunteers will be performed. Healthy and physically active individuals, aged between 18 and 35 years, with no history of injury on the lower limbs or contra-indications to maximal exercise performance will be included. A protocol of 10 series with 10 repetitions of the countermovement jump will be used to induce muscle damage at the lower limbs. Immediately before or after the exercise protocol, LLLT will be applied on one lower limb, while the other will receive placebo treatment. Phototherapy will be applied with an equipment of 810nm and a cluster with 5 diodes on 8 different points of the knee extensor muscle, totalizing a dosage of 240J. The placebo treatment will be held on the same way, but the equipment will be turned off. The volunteers will be evaluated at baseline (before the exercise protocol) and at follow-up of 24, 48 and 72 hours. The following outcomes will be evaluated: knee extensors isometric peak torque by Isokinetic Dynamometer, pain by Visual Analogue Scale and muscular tissue echo intensity by Ultrasonography.

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Key information

Conditions

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Federal University of Health Science of Porto Alegre

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy males aged between 18 and 35 years;
  • Sedentary or physically active individuals who exercise up to 3 times per week.

Exclusion criteria

  • Individuals who participate in systematic exercise training;
  • Individuals who participate in strength training for the lower limbs;
  • Individuals with lower or upper limb injuries;
  • Individuals with contra-indications to maximal exercise performance (due to neurological, cardiovascular or respiratory conditions);
  • Individuals who show difficulties to understand the study protocol.

Treatment and study plan

LLLT before muscle damage

Device

Placebo LLLT before muscle damage

Device

LLLT after muscle damage

Device

Placebo LLLT after muscle damage

Device

Primary outcomes

  1. Knee extensors isometric peak torque (Nm)

    Time frame: Baseline and 24, 48 and 72 hours follow-up

    Isokinetic Dynamometer

Secondary outcomes

  1. Knee extensors soreness (Visual Analogue scale)

    Time frame: Baseline and 24, 48 and 72 hours follow-up

  2. Knee extensors echo intensity (number of white and black pixels)

    Time frame: Baseline and 24, 48 and 72 hours follow-up

Sponsors and collaborators

Lead sponsor

Federal University of Health Science of Porto Alegre

Other

Registry information

Official study title

Effect of Low-level Laser Therapy on Exercise-induced Muscle Damage: a Randomized Clinical Trial

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Jul 9, 2015
Registry last updated
Oct 15, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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