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OpenTrials
Completed

NCT Number: NCT06677385

Effect of Low-Level Laser on Crevicular Interleukin-1β Concentration in Patients With Periodontal Disease: A Relation to Periodontal Inflammaging

This study is done to compare between young age and old age patients with periodontitis (inflammaging) and the effect of diode laser as adjunctive to scaling and debridement

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Key information

Conditions

Periodontal Diseases Mouth Diseases Old Age Stomatognathic Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Misr University foe Science and Technology

Giza, Giza Governorate, 0000, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or Female
  • Aged below 40 or above 60.
  • Provide informed consent and willingness to cooperate with study protocol.
  • Periodontitis stage II patients:
  • CAL from 3-4 mm.
  • Radiographic bone loss (15% to 33%).
  • No tooth loss due to periodontitis.
  • Maximum probing depth ≤ 5 mm, mostly horizontal bone loss

Exclusion criteria

  • Patients with heavy smoking habits
  • History of antibiotics in the previous three months.
  • Pregnant or lactating female.
  • Treatment with any systemic drug.
  • History of systemic disease.
  • Patients who received periodontal treatment in the last 6 months

Treatment and study plan

diode laser as adjunctive to conventional scaling and debridement

Radiation

diode laser as adjunctive to conventional scaling and debridement for old age patients

conventional scaling and debridement

Procedure

conventional scaling and debridement

Primary outcomes

  1. Gingival index

    Time frame: first visit, second follow up after 1 month and final follow up after 6 months

  2. Clinical attachment loss

    Time frame: first visit, second follow up after 1 month and final follow up after 6 months

  3. Interleukin 1 beta

    Time frame: first visit, second follow up after 1 month and final follow up after 6 months

    collected and analyzed by ELISA from Gingival crevicular fluid and blood serum

Sponsors and collaborators

Lead sponsor

Misr University for Science and Technology

Other

Registry information

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Nov 6, 2024
Registry last updated
Feb 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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