Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women

Intervention studying the effect of a low-carbohydrate/high-fat (LCHF) diet as well as on bout of exercise in combination with either a normal diet or a LCHF diet, in relation to glucose metabolism, insulin sensitivity, lipid profile and body composition.

Completed

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Key information

Conditions

Insulin Sensitivity Body Weight Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms Weight

Age range

18 year–30 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Norwegian School of Sport Sciences

Oslo, 0806, Norway

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Females
Normal weight
BMI between 18.5 and 25
Moderately trained

Exclusion criteria

Smokers/tobacco users
pregnancy
familial cardio-vascular-disease
diabetes or reduced glucose tolerance
under- or overweight (BMI under 18.5 or over 25)
top athletes

Treatment and study plan

LCHF diet and a bout of exercise

Other

Low-carbohydrate/high-fat diet; effect on insulin sensitivity, lipid profile, weight and body composition. Participants ingested LCHF diet for three weeks before undergoing an oral glucose tolerance test. The same afternoon the participated in an one hour indoor bicycle training at 75% at HFpeak. The following morning they underwent a new oral glucose tolerance test. Body composition and weight were measured before and after the intervention. Oral glucose tolerance test was also performed before the intervention for baseline. Blood samples were collected before and after the intervention for lipid profile analyses.

Primary outcomes

Area under the curve glucose (0, 15, 30, 45, 60, 90 and 120 min)

Time frame: -1 week, 3 weeks

performed by oral glucose tolerance test, 75 g glucose, 300 ml water

Sponsors and collaborators

Lead sponsor

Atlantis Medical University College

Other

Collaborators

Norwegian School of Sport Sciences

Registry information

Acronym: LCHF

Important dates

Study start: 2012
Primary completion: 2012
Study completion: 2013
First posted: Dec 9, 2013
Registry last updated: Dec 9, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed