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Completed

NCT Number: NCT05899686

Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia

The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.

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Key information

Conditions

Stress Reaction Fractures, Bone Fractures, Stress Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of California San Francisco

San Francisco, California, 94134, United States

About this study

A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations (Ulnar nerve, Facial nerve, Posterior Tibial nerve) in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplethysmography.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Surgical patients
  • Undergoing general anesthesia
  • Able to consent in english
  • 18 years of age or older

Exclusion criteria

  • Under 18 years of age
  • unable to consent in english
  • receiving regional anesthesia

Treatment and study plan

Tetanic Stimulus

Device

5 second 100 Hz 70 mA tetanic stimulus will be applied to three different anatomical locations in each subject.

Primary outcomes

  1. Tetanic Stimulus Induced Change in Photoplethysmography Light Transmission (in Analog to Digital Units as Measured Using a Pulse Oximeter) From Pre Stimulus Baseline

    Time frame: Maximum light transmission change from pre tetanic stimulus baseline within 60 seconds after the tetanic stimulus

    Tetanic stimulation will induce peripheral vasoconstriction. This will be measured using photoplethysmography. During peripheral vasoconstriction the light transmission through finger will increase. The primary outcome will be the maximum change in light transmission (as measured by photoplethysmography) within 60 seconds after a tetanic stimulus as compared to pre stimulus baseline values. These maximal light transmission changes will be compared between the three different tetanic stimulus sites

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Official study title

Effect of Tetanic Stimuli on Photoplethysmogram During General Anesthesia

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Jun 12, 2023
Registry last updated
May 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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