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NCT Number: NCT03648853

Effect of Location of Tetanic Stimuli on Photoplethysmogram

The effect of the location of tetanic stimulus on photoplethysmography signals will be studies in patients under general anesthesia.

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Key information

Conditions

Stress Reaction Fractures, Bone Fractures, Stress Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of California San Francisco

San Francisco, California, 94122, United States

About this study

A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplythysmography.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Surgical patients general anesthesia able to consent in english

Exclusion criteria

  • regional anesthesia unable to consent in english under 18 yrs of age

Treatment and study plan

Tetanic Stimulus

Device

5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order

Primary outcomes

  1. Photoplethysmography (PPG)

    Time frame: 1-2 minutes

    Change in the PPG signal in response to tetanic stimulus. A tetanic stimulus will cause vasoconstriction which can be recorded as a decrease in PPG AC/DC. The outcome measure is the maximum decrease in AC/DC from baseline. Maximum decrease happens typically in 30-60 seconds after the stimulus. Thus, data was collected immediately before (baseline) and for 2 min after the stimulus. After the stimulus AC/DC values return to baseline in a few minutes. Baseline AC/DC measures a relative state of blood vessel tone. In anesthetized patients the AC/DC values can range from close to 0 to above 10. The higher the value, the more vasodilated the subject is.

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Official study title

Effect of Location of Tetanic Stimuli on Photopethysmogram During General Anesthesia

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Aug 27, 2018
Registry last updated
May 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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