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OpenTrials
Completed

NCT Number: NCT00846183

Effect of Local Injury on Implantation

Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.

Completed

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Key information

Conditions

Implantation Rate

Age range

Up to 35 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2

Primary location

Research and clinical center for infertility

Yazd, Yazd Province, Iran

About this study

Low implantation rate is still a major concern in ART cycles. It has been reported that local injury to endometrium may improve endometrial receptivity and implantation rate. A total of 120 patients in first IVF cycles, who are stimulated with long protocol, are randomly divided into two groups. In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed and in the other group no interventions are done. After fresh embryo transfers, implantation and clinical pregnancy rates are compared between two groups.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age < 35
  • First IVF cycle
  • Long protocol should be used for stimulation

Exclusion criteria

  • Day 3 FSH > 10

Treatment and study plan

local injury

Procedure

In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed

Other names: it does not have other name

Primary outcomes

  1. implantation rate

    Time frame: 4 weeks

Secondary outcomes

  1. clinical pregnancy rate

    Time frame: 4 weeks

Sponsors and collaborators

Lead sponsor

Yazd Research & Clinical Center for Infertility

Other

Registry information

Official study title

Effect of Local Injury to Endometrium on the Day of Oocyte Retrieval in First IVF Cycle on Implantation Rate.

Important dates

Study start
2008
Primary completion
2008
Study completion
2009
First posted
Feb 18, 2009
Registry last updated
Dec 23, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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